AF 698
- Product Name
- AF 698
- CAS No.
- 82958-11-0
- Chemical Name
- AF 698
- Synonyms
- AF 698;(3α,16α)-Eburnamenine-14-carboxylic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester;Eburnamenine-14-carboxylic acid, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (3α,16α)- (9CI)
- CBNumber
- CB71351836
- Molecular Formula
- C28H26N2O4
- Formula Weight
- 454.52
- MOL File
- 82958-11-0.mol
AF 698 Property
- Boiling point:
- 571.1±50.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- pka
- 7.68±0.60(Predicted)
AF 698 Chemical Properties,Usage,Production
Description
AF 698 is a peripheral vasodilator. AF 698 may have a protective effect against the lethalality of hypobaric hypoxia.
Uses
AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice[1].
References
[1] Marzo, et al. A new phthalidyl derivative of apovincaminic acid:(3 alpha, 16 alpha)-eburnamenine-14 carboxylic acid phthalidyl ester (AF 698). A preliminary report on its chemical and pharmacological properties. Arzneimittel-forschung 32.6 (1982): 601-603. PMID:7202363
AF 698 Preparation Products And Raw materials
Raw materials
Preparation Products
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