amfenac Property

Melting point:

121-123° (dec)

Boiling point:

398.5°C (rough estimate)

Density 

1.1654 (rough estimate)

refractive index 

1.5500 (estimate)

Safety

Toxicity

LD50 in mice, rats (mg/kg): 615, 311 orally (Sancilio)

Hazard and Precautionary Statements (GHS)

amfenac Chemical Properties,Usage,Production

Originator

Amfenac sodium,Yungjin Pharmacetical Co. Ltd.

Uses

Anti-inflammatory.

Definition

ChEBI: An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used fo the treatment of pain and inflammation following cataract surgery.

Manufacturing Process

7-Benzoylindolin-2-one:
Method A. A mixture of 2.5 g (0.0077 mole) of ethyl 2-acetamido-3- benzoylphenylacetate in 50 ml of 3 N hydrochloric acid was refluxed for one hour. The reaction mixture was filtered and the filtrate was poured into a mixture of ice and water. The precipitate was collected and recrystallized from acetone; yield of 7-benzoylindolin-2-one 1 g (55%); melting point 154°C.
Method B. A solution of 1.3 g (0.0044 mole) of 2-acetamido-3- benzoylphenylacetic acid in 15 ml of 3 N hydrochloric acid and 15 ml of acetic acid was refluxed for three hours. The cooled solution was poured into ice water and the 7-benzoylindolin-2-one which precipitated was collected and dried.
2-Amino-3-benzoylphenylacetic acid:
A mixture of 1.0 g (0.004 mole) of 7-benzoylindolin-2-one was added to 30 ml of 3 N sodium hydroxide and the basic solution was refluxed for 45 min under nitrogen. The mixture was filtered and the filtrate was neutralized with glacial acetic acid. The precipitate was filtered off, washed with water and dried. The 2-amino-3-benzoylbenzeneacetic acid melted at 122°C (dec.). The yield was 0.8 g (72%).

Therapeutic Function

Antiinflammatory