4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid

Product Name: 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid
CAS No.: 171746-21-7
Chemical Name: 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid
Synonyms: CD 3106;AGN 193109;AGN 193109 SodiuM Salt;AGN 193109, 10 mM in DMSO;4-((5,5-Dimethyl-8-p-tolyl-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid;4-{[5,5-diMethyl-8-(4-Methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid;4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid;Benzoic acid, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-;AGN193109,Autophagy,Inhibitor,Retinoic acid receptors,Retinoid X receptors,RAR/RXR,AGN 193109,AGN-193109,inhibit
CBNumber: CB71359968
Molecular Formula: C28H24O2
Formula Weight: 392.49
MOL File: 171746-21-7.mol

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4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Property

Melting point:: 246-255?C
Boiling point:: 564.5±50.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly, Sonicated)
form: Solid
pka: 4.08±0.10(Predicted)
color: Off-White to Pale Yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23975
Product name: AGN 193109 (sodium salt)
Packaging: 500μg
Price: $107
Updated: 2023/01/06

Cayman Chemical

Product number: 23975
Product name: AGN 193109 (sodium salt)
Packaging: 1mg
Price: $204
Updated: 2023/01/06

Tocris

Product number: 5758
Product name: AGN193109
Purity: ≥98%(HPLC)
Packaging: 10
Price: $303
Updated: 2021/12/16

TRC

Product number: A427000
Product name: AGN193109SodiumSalt
Packaging: 10mg
Price: $1455
Updated: 2021/12/16

TRC

Product number: A427000
Product name: AGN193109SodiumSalt
Packaging: 1mg
Price: $185
Updated: 2021/12/16

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4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

As a retinoic acid receptor (RAR) antagonist, 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid can be used for treating chemotherapy and radiation therapy side effects.

Biological Activity

AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist th at targets all three RAR subtypes with higher affinity (RARα/β/γ Kd = 2 nM) than all-trans retinoic acid/ATRA (RARα/β/γ Kd = 9/12/19 nM). AGN 193109 potently antagonizes against ATRA-induced transcription in RARα, RARβ, and RARγ transfected CV-1 cells (by 85%, 62%, and 100%, respectively, by equal molar AGN 193109 against ATRA). AGN 193109 is also widely employeed to block RAR-mediated physiological and pathalogical processes in mice and rats in vivo via oral (1-10 mg/kg) or topical (0.3-36 μmol/kg) administration.

storage

Store at -20°C

4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid Suppliers

Canada 1 CHINA 41 United Kingdom 1 United States 7 Global 50

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171746-21-7, 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acidRelated Search:

Dimethyl Dimethylhydrochlorosilane DIMETHYLCYANAMIDE N,N-Dimethylaniline 5,5-Dimethylhydantoin

AGN 193109

4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid

CD 3106

4-((5,5-Dimethyl-8-p-tolyl-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid

4-{[5,5-diMethyl-8-(4-Methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid

AGN 193109 SodiuM Salt

Benzoic acid, 4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-

AGN193109,Autophagy,Inhibitor,Retinoic acid receptors,Retinoid X receptors,RAR/RXR,AGN 193109,AGN-193109,inhibit

AGN 193109, 10 mM in DMSO

171746-21-7

Aromatics Compounds

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals