tomaymycin

Product Name: tomaymycin
CAS No.: 35050-55-6
Chemical Name: tomaymycin
Synonyms: NSC 177499;tomaymycin;2-Ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one;(2E,11R,11aS)-2-Ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one;5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-, (2E,11R,11aS)-
CBNumber: CB71368984
Molecular Formula: C16H20N2O4
Formula Weight: 304.34
MOL File: 35050-55-6.mol

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tomaymycin Property

Melting point:: 145.5°C
Boiling point:: 445.17°C (rough estimate)
Density: 1.1328 (rough estimate)
refractive index: 1.5800 (estimate)
pka: 8.66±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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tomaymycin Chemical Properties,Usage,Production

Uses

Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria[1][2].

Definition

ChEBI: (E)-tomaymycin is the (E)-isomer of tomaymycin.

in vivo

Tomaymycin, an antiphage antibiotic is produced by cultivation of Streptomyces achromogenes var. tomaymyceticus in a lactose-bouillon medium enriched with yeast extract and phosphate salts. The antiphage activity is strong against Escherichia coli T1, T3 phages and Bacillus subtilis M-2, SP-10 phages. The LD₅₀ (i.p.) of tomaymycin for mice is estimated at 3.0 mg/kg.

References

[1] F L Boyd, et al. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 1990 Mar 6;29(9):2387-403. DOI:10.1021/bi00461a024
[2] K Arima, et al. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo). 1972 Aug;25(8):437-44. DOI:10.7164/antibiotics.25.437

tomaymycin Preparation Products And Raw materials

Raw materials

Preparation Products

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tomaymycin Suppliers

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35050-55-6, tomaymycinRelated Search:

1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one (S)-(-)-1-BENZYL-2-PYRROLIDINEMETHANOL 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPIN-7-OL tomaymycin (2-AMINO-PHENYL)-PYRROLIDIN-1-YL-METHANONE

tomaymycin

2-Ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

(2E,11R,11aS)-2-Ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

NSC 177499

5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-, (2E,11R,11aS)-

35050-55-6