glucopiericidin A
- Product Name
- glucopiericidin A
- CAS No.
- 108073-65-0
- Chemical Name
- glucopiericidin A
- CBNumber
- CB71378053
- Molecular Formula
- C31H47NO9
- Formula Weight
- 577.71
- MOL File
- 108073-65-0.mol
N-Bromosuccinimide Price
- Product number
- INB0003868
- Product name
- GLUCOPIERICIDIN A
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.48
- Updated
- 2021/12/16
glucopiericidin A Chemical Properties,Usage,Production
Uses
Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts[1][2].
in vivo
Glucopiericidin A (0.8 mg/kg/day; IP; for three weeks) significantly reduces the final tumor weight of the mice[2].
| Animal Model: | Nude mice bearing ACHN tumor xenografts[2] |
| Dosage: | 0.8 mg/kg |
| Administration: | IP; daily; for three weeks |
| Result: | Significantly reduced the final tumor weight of the mice. Increased the mRNA and protein expression of PRDX1 in tumor tissues. |
References
[1] Mitsuhiro Kitagawa, et al. Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. Chem Biol. 2010 Sep 24;17(9):989-98. DOI:10.1016/j.chembiol.2010.06.017
[2] Xuefeng Zhou, et al. Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. J Med Chem. 2019 Aug 8;62(15):7058-7069. DOI:10.1021/acs.jmedchem.9b00598
glucopiericidin A Preparation Products And Raw materials
Raw materials
Preparation Products
glucopiericidin A Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 0571-89903882 18679456698
- mingxinzhu@huidabiotech.com
- Country
- China
- ProdList
- 2975
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 0571-0571-89903882 15990081639
- sunshixuan@huidabiotech.com
- Country
- China
- ProdList
- 3705
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9835
- Advantage
- 58