altertoxin I

altertoxin I Property

Boiling point:

699.8±55.0 °C(Predicted)

Density 

1.694±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Dichloromethane: 10 mg/ml

form 

A powder

pka

7.54±0.60(Predicted)

biological source

rabbit

Safety

RIDADR 

3172

HazardClass 

6.1(b)

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

altertoxin I Chemical Properties,Usage,Production

Uses

Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication[1].

References

[1] Jarolim K, et al. Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II. Arch Toxicol. 2017 Jan;91(1):203-216. DOI:10.1007/s00204-016-1726-7
[2] Boutin BK, et al. Effects of purified altertoxins I, II, and III in the metabolic communication V79 system. J Toxicol Environ Health. 1989;26(1):75-81. DOI:10.1080/15287398909531234
[3] Stack ME, et al. Mutagenicity of the Alternaria metabolites altertoxins I, II, and III. Appl Environ Microbiol. 1986 Oct;52(4):718-22. DOI:10.1128/aem.52.4.718-722.1986