neplanocin A

Product Name: neplanocin A
CAS No.: 72877-50-0
Chemical Name: neplanocin A
Synonyms: A-11079B16;NephanocinA;neplanocin A;Neoplanocin A;3-Neplanocin A;(?)-Neplanocin A;Antibiotic A-11079B16;()-Neplanocin A Exclusive;(?)-Neplanocin A Exclusive;3-Cyclopentene-1,2-diol, 5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-
CBNumber: CB71397173
Molecular Formula: C11H13N5O3
Formula Weight: 263.25
MOL File: 72877-50-0.mol

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neplanocin A Property

Melting point:: 214-216 °C (decomp)
Boiling point:: 632.6±65.0 °C(Predicted)
Density: 1.91±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 0.2 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.3 mg/ml
form: A crystalline solid
pka: 13.43±0.70(Predicted)
color: White to off-white
InChI: InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1
InChIKey: XUGWUUDOWNZAGW-VDAHYXPESA-N
SMILES: [C@H]1(O)[C@H](N2C3C(N=C2)=C(N)N=CN=3)C=C(CO)[C@H]1O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10584
Product name: (?)-Neplanocin A
Purity: ≥98%
Packaging: 500μg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 10584
Product name: (?)-Neplanocin A
Purity: ≥98%
Packaging: 1mg
Price: $510
Updated: 2024/03/01

Cayman Chemical

Product number: 10584
Product name: (?)-Neplanocin A
Purity: ≥98%
Packaging: 5mg
Price: $2096
Updated: 2024/03/01

AK Scientific

Product number: 4504CA
Product name: NeplanocinA
Packaging: 1mg
Price: $667
Updated: 2021/12/16

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neplanocin A Chemical Properties,Usage,Production

Description

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (K_i = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID₅₀ = 0.07 and 0.3 μg/ml, respectively).

Uses

Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis[1].

References

[1] Borchardt RT, Keller BT, Patel-Thombre U. Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells. J Biol Chem. 1984 Apr 10;259(7):4353-8. PMID:6707008

neplanocin A Preparation Products And Raw materials

Raw materials

Preparation Products

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neplanocin A Suppliers

China 16 United States 2 Global 18

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72877-50-0, neplanocin ARelated Search:

neplanocin A

A-11079B16

Antibiotic A-11079B16

Neoplanocin A

3-Neplanocin A

()-Neplanocin A Exclusive

3-Cyclopentene-1,2-diol, 5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-

(?)-Neplanocin A

(?)-Neplanocin A Exclusive

NephanocinA

72877-50-0