9-hydroxystearic acid Property

Melting point:

74-75 °C

Boiling point:

433.9±28.0 °C(Predicted)

Density 

0.944±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Chloroform: soluble

form 

A solid

pka

4.78±0.10(Predicted)

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

9-hydroxystearic acid Chemical Properties,Usage,Production

Definition

ChEBI: 9-hydroxyoctadecanoic acid is a hydroxyoctadecanoic acid that is octadecanoic acid (stearic acid) which has been substituted by a hydroxy group at position 9. It is a conjugate acid of a 9-hydroxyoctadecanoate.

Biological Activity

9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA .1,2 It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 μM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates.3 It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 μM.1

References

1.Calonghi, N., Cappadone, C., Pagnotta, E., et al.9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cellsBiochem. Biophys. Res. Commun.314(1)138-142(2004) 2.Kolar, M.J., Kamat, S.S., Parsons, W.H., et al.Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipaseBiochemistry55(33)4636-4641(2016) 3.Calonghi, N., Cappadone, C., Pagnotta, E., et al.Histone deacetylase 1: A target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancerJ. Lipid Res.46(8)1596-1603(2005)