ChemicalBook > CAS DataBase List > 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol

Product Name
4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol
CAS No.
68592-15-4
Chemical Name
4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol
Synonyms
4-O-Methyl honokiol;4'-O-Methylhonokiol;4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol;4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol;4'-methoxy-3',5-di-2-propyleneyl-(1,1'-biphenyl)-2-ol;2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol;[1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl-
CBNumber
CB71401542
Molecular Formula
C19H20O2
Formula Weight
280.36
MOL File
68592-15-4.mol
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4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol Property

Boiling point:
396.461±30.00 °C(Press: 760.00 Torr)(predicted)
Density 
1.054±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
form 
Viscous Liquid
pka
9.905±0.43(predicted)
color 
Orange to red
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0035406
Product name
4-O-Methylhonokiol
Purity
99.65%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0035406
Product name
4-O-Methylhonokiol
Purity
99.65%
Packaging
10mg
Price
$800
Updated
2021/12/16
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4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol Chemical Properties,Usage,Production

Uses

4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.

in vivo

4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues[1]. 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain[2].

IC 50

PPARγ; NF-κB

References

[1] Lee NJ, et al. 4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity. Br J Pharmacol. 2013 Mar;168(5):1133-45. DOI:10.1111/j.1476-5381.2012.02235.x
[2] Lee YJ, et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation. 2012 Feb 19;9:35. DOI:10.1186/1742-2094-9-35

4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol Suppliers

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68592-15-4, 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-olRelated Search:


  • 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol
  • 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
  • 4-O-Methyl honokiol
  • [1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl-
  • 4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol
  • 4'-O-Methylhonokiol
  • 4'-methoxy-3',5-di-2-propyleneyl-(1,1'-biphenyl)-2-ol
  • 68592-15-4
  • 8592-15-4
  • novel chemicals