ISOEGOMAKETONE
- Product Name
- ISOEGOMAKETONE
- CAS No.
- 34348-59-9
- Chemical Name
- ISOEGOMAKETONE
- Synonyms
- ISOEGOMAKETONE;(2E)-1-(3-Furyl)-4-methyl-2-penten-1-one;(E)-1-(furan-3-yl)-4-methylpent-2-en-1-one;(2E)-1-(Furan-3-yl)-4-methylpent-2-en-1-one;2-Penten-1-one, 1-(3-furanyl)-4-methyl-, (2E)-;(E)-1-(Furan-3-yl)-4-methylpent-2-en-1-one - [F90363]
- CBNumber
- CB71405979
- Molecular Formula
- C10H12O2
- Formula Weight
- 164.2
- MOL File
- 34348-59-9.mol
ISOEGOMAKETONE Property
- Boiling point:
- 70 °C(Press: 1 Torr)
- Density
- 1.002±0.06 g/cm3(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- INB0001909
- Product name
- ISOEGOMAKETONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.02
- Updated
- 2021/12/16
ISOEGOMAKETONE Chemical Properties,Usage,Production
Uses
Isoegomaketone is a sesquiterpenoid that can be isolated from Perilla frutescens essential oil. Isoegomaketone exhibits anti-inflammatory, antioxidant, anti-cancer, anti-mycobacterial, anti-arthritic and anti-obesity effects[1][2][3].
Definition
ChEBI: Isoegomaketone is an aromatic ketone.
Synthesis Reference(s)
Synthesis, p. 991, 1984 DOI: 10.1055/s-1984-31051
Anticancer Research
This compound tested in in vivo models of B16 melanoma gave a significant cellgrowth inhibition. The tumor cells show an ROS-mediated mitochondria-dependentapoptotic-type death in sub-G1 cell cycle. Iso-egomaketone seemed to generateROS in cells as well as upregulation of Bax and Bcl-2expression (Russo et al. 2015;Shen et al. 2012).
References
[1] Ba?er K H C, et al., Composition of the essential oil of Perilla frutescens (L.) Britton from Turkey[J]. Flavour and fragrance journal, 2003, 18(2): 122-123.
[2] Kim HM, et al., 9?Hydroxy?isoegomaketone inhibits LPS?induced NO and inflammatory cytokine production in RAW264.7 cells. Mol Med Rep. 2021 Mar;23(3):181. DOI:10.3892/mmr.2020.11820
[3] Kim HW, et al., Isoegomaketone exhibits potential as a new Mycobacterium abscessus inhibitor. Front Microbiol. 2024 Feb 23;15:1344914. DOI:10.3389/fmicb.2024.1344914
ISOEGOMAKETONE Preparation Products And Raw materials
Raw materials
Preparation Products
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