1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide

Product Name: 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
CAS No.: 2648418-86-2
Chemical Name: 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
Synonyms: DGKα-IN-3;3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]dec-8-yl]-;1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide
CBNumber: CB714213224
Molecular Formula: C26H27F3N4O3
Formula Weight: 500.51
MOL File: 2648418-86-2.mol

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1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Property

Boiling point:: 634.854±55.00 °C(Press: 760.00 Torr)(predicted)
Density: 1.423±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka: 14.711±0.20(predicted)

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Hazard and Precautionary Statements (GHS)

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1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Chemical Properties,Usage,Production

Uses

DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.

References

[1] Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide Suppliers

China 1 United States 1 Global 2

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
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TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19957
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2648418-86-2, 1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamideRelated Search:

1-Methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]decan-8-yl]-1,2-dihydroquinoline-3-carboxamide

DGKα-IN-3

3-Quinolinecarboxamide, 1,2-dihydro-1-methyl-2-oxo-4-[2-[4-(trifluoromethoxy)phenyl]-2,8-diazaspiro[4.5]dec-8-yl]-

2648418-86-2