1,2,3,4,5,6,7,8,9-NONACHLORODECANE

Product Name: 1,2,3,4,5,6,7,8,9-NONACHLORODECANE
CAS No.: 2366268-80-4
Chemical Name: 1,2,3,4,5,6,7,8,9-NONACHLORODECANE
Synonyms: CP-10;1,2,3,4,5,6,7,8,9-NONACHLORODECANE;4-((2-(2-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(2-{2-[4-({4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber: CB7142721
Molecular Formula: C44H49N13O7
Formula Weight: 871.94
MOL File: Mol file

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1,2,3,4,5,6,7,8,9-NONACHLORODECANE Property

Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 200 mg/mL (229.37 mM)
form: Solid
pka: 10.74±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0100994
Product name: CP-10
Purity: 98.03%
Packaging: 5mg
Price: $880
Updated: 2021/12/16

ChemScene

Product number: CS-0100994
Product name: CP-10
Purity: 98.03%
Packaging: 10mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0100994
Product name: CP-10
Purity: 98.03%
Packaging: 50mg
Price: $2650
Updated: 2021/12/16

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1,2,3,4,5,6,7,8,9-NONACHLORODECANE Chemical Properties,Usage,Production

Uses

CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].

IC 50

CDK6: 2.1 nM (DC₅₀); Cereblon

References

[1] Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2. DOI:10.1021/acs.jmedchem.9b00871

1,2,3,4,5,6,7,8,9-NONACHLORODECANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4,5,6,7,8,9-NONACHLORODECANE Suppliers

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2366268-80-4, 1,2,3,4,5,6,7,8,9-NONACHLORODECANERelated Search:

CP-10

1,2,3,4,5,6,7,8,9-NONACHLORODECANE

1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

4-((2-(2-(4-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-[(2-{2-[4-({4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

2366268-80-4