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4-Boc-1-piperazineacetic acid

Product Name
4-Boc-1-piperazineacetic acid
CAS No.
156478-71-6
Chemical Name
4-Boc-1-piperazineacetic acid
Synonyms
4-Boc-piperazineacetic Acid;4-Boc-1-piperazineacetic acid;BOC-4-CARBOXYMETHYLPIPERAZINE;2-(4-Boc-piperazino)acetic acid;4-N-BOC-1-Piperazineacetic acid;1-BOC-4-CARBOXYMETHYL PIPERAZINE;(1-BOC-PIPERAZIN-4-YL)ACETIC ACID;2-(4-Boc-1-piperazinyl)acetic acid;2-(1-Boc-piperazin-4-yl)-acetic aci;2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID
CBNumber
CB7144710
Molecular Formula
C11H20N2O4
Formula Weight
244.29
MOL File
156478-71-6.mol
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4-Boc-1-piperazineacetic acid Property

Boiling point:
365.5±37.0 °C(Predicted)
Density 
1.174
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
2.40±0.10(Predicted)
form 
Solid
color 
Off-white to gray
InChI
InChI=1S/C11H20N2O4/c1-11(2,3)17-10(16)13-6-4-12(5-7-13)8-9(14)15/h4-8H2,1-3H3,(H,14,15)
InChIKey
WZBHMXRBXXCEDD-UHFFFAOYSA-N
SMILES
N1(CC(O)=O)CCN(C(OC(C)(C)C)=O)CC1
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B809875
Product name
2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)aceticAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B809875
Product name
2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)aceticAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
Usbiological
Product number
264137
Product name
1-Boc-4-carboxymethyl piperazine
Packaging
250mg
Price
$347
Updated
2021/12/16
AK Scientific
Product number
C032
Product name
1-Boc-4-carboxymethylpiperazine
Packaging
1g
Price
$27
Updated
2021/12/16
Matrix Scientific
Product number
042385
Product name
Boc-(4-carboxymethyl)piperazine
Purity
95+%
Packaging
1g
Price
$39
Updated
2021/12/16
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4-Boc-1-piperazineacetic acid Chemical Properties,Usage,Production

Uses

1-Boc-4-carboxymethyl piperazine is a PROTAC linker. 1-Boc-4-carboxymethyl piperazine can be used in the synthesis of PROTACs (e.g. PROTAC IRAK4 degrader-12 (HY-168586))[1].

Synthesis

209667-59-4

156478-71-6

b) General procedure for the synthesis of 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid: to a solution of tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate (1.5 g, 5.51 mmol) in methanol (10 ml) was added an aqueous solution of sodium hydroxide (0.8 g, 22.0 mmol, 4 equiv). The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the mixture was concentrated and extracted according to the method of Intermediate Example 5 (c). The solvent was removed by distillation to give the target product in 76% (1 g) yield. The product was characterized by LC-MS (ESI): calculated mass: 244.29; observed mass: 145.1 [M-Boc + H]+ (retention time: 0.102 min).

References

[1] Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1.WIPO, 2024-10-03.

4-Boc-1-piperazineacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Boc-1-piperazineacetic acid Suppliers

Canada 1 China 95 Germany 3 India 1 United Kingdom 3 United States 16 Global 119
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
CHESS GmbH
Tel
--
Fax
--
Email
chess-chemie@T-online.de
Country
Germany
ProdList
605
Advantage
65
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 4-Boc-1-piperazineacetic acid manufacturers

Career Henan Chemical Co
Product
4-Boc-1-piperazineacetic acid 156478-71-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10
Career Henan Chemical Co
Product
4-Boc-1-piperazineacetic acid 156478-71-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

156478-71-6, 4-Boc-1-piperazineacetic acidRelated Search:

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  • 2-(1-Boc-piperazin-4-yl)-acetic acid dihydrate
  • 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid
  • 2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID
  • [4-(tert-Butoxycarbonyl)-1-piperazinyl]acetic acid
  • 4-Boc-1-piperazineacetic acid
  • 2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID 2 H2O
  • 2-(1-TERT-BUTOXYCARBONYL-PIPERAZIN-4-YL)-ACETIC ACID 2 H2O
  • 4-Carboxymethylpiperazine-1-carboxylic acid tert-butyl ester
  • (1-BOC-PIPERAZIN-4-YL)ACETIC ACID
  • 2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID X 2 H2O
  • 2-(1-tert-Butoxycarbonyl-piperazin-4-yl)-acetic acid x 2 H2O
  • 1-Piperazineacetic acid, 4-[(1,1-diMethylethoxy)carbonyl]-
  • [1-(tert-Butoxycarbonyl)piperazin-4-yl]acetic acid
  • 2-(1-Boc-Piperazin-4-yl)-acetic acid hydrate
  • tert-Butyl 4-(carboxymethyl)piperazine-1-carboxylate
  • 4-Boc-piperazineacetic Acid
  • 2-(4-Boc-1-piperazinyl)acetic acid
  • 2-(4-Boc-piperazino)acetic acid
  • 2-(1-Boc-piperazin-4-yl)-acetic aci
  • 2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]acetic acid
  • 4-N-BOC-1-Piperazineacetic acid
  • 156478-71-6
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