Fmoc-Tyr-OtBu
- Product Name
- Fmoc-Tyr-OtBu
- CAS No.
- 133852-23-0
- Chemical Name
- Fmoc-Tyr-OtBu
- Synonyms
- Fmoc-Tyr-OtBu;Fmoc-L-Tyr-OtBu;N-Fmoc-L-tyrosine tert-butyl ester;"L-Tyrosine (Tbu)-OH-13C9,15N, Fmoc";(9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr-OtBu;tert-butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-tyrosinate;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester;L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1,1-dimethylethyl ester;tert-butyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-hydroxyphenyl)propanoate
- CBNumber
- CB71456704
- Molecular Formula
- C28H29NO5
- Formula Weight
- 459.53
- MOL File
- 133852-23-0.mol
Fmoc-Tyr-OtBu Property
- Boiling point:
- 655.9±55.0 °C(Predicted)
- Density
- 1.219±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.75±0.15(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C382138
- Product name
- Fmoc-Tyr-OtBu
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AS112763
- Product name
- Fmoc-Tyr-OtBu
- Purity
- 95%
- Packaging
- 5G
- Price
- $52
- Updated
- 2021/12/16
- Product number
- AS112763
- Product name
- Fmoc-Tyr-OtBu
- Purity
- 95%
- Packaging
- 25g
- Price
- $159
- Updated
- 2021/12/16
- Product number
- AS112763
- Product name
- Fmoc-Tyr-OtBu
- Purity
- 95%
- Packaging
- 100g
- Price
- $507
- Updated
- 2021/12/16
- Product number
- A151978
- Product name
- Fmoc-Tyr-OtBu
- Purity
- 95%
- Packaging
- 500g
- Price
- $1615
- Updated
- 2021/12/16
Fmoc-Tyr-OtBu Chemical Properties,Usage,Production
Synthesis
16874-12-7
82911-69-1
133852-23-0
General procedure: tert-butyl L-tyrosine (1.00 g, 4.21 mmol) and sodium bicarbonate (354 mg, 4.21 mmol) were suspended in 1,4-dioxane/water (1:1, 20 mL) with stirring. To this suspension was added 9-fluorenylmethyl-N-succinimidyl carbonate (1.42 g, 4.21 mmol), and the resulting mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the solvent was concentrated under reduced pressure to about 10 mL. cold 1N hydrochloric acid (50 mL) was added and the product was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed sequentially with water and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give the colorless solid product 83 (1.94 g, 100%), which could be used in the next reaction without further purification. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.43 (s, 9H), 2.97-3.06 (m, 2H), 4.21 (bt, J = 7.1 Hz, 1H), 4.33 (dd, J = 7.1, 10.5 Hz, 1H), 4.41-4.53 (m, 2H), 5.01 (bs, 1H), 5.30 (d, J = 8.2 Hz, 1H), 6.73 (d, J = 8.5 Hz, 2H), 7.00 (d, J = 8.5 Hz, 2H), 7.31 (t, J = 7.5 Hz, 2H), 7.40 (t, J = 7.5 Hz, 2H), 7.57 (dd, J = 3.3, 7.3 Hz, 2H), 7.76 (d, J = 7.5 Hz 2H).
References
[1] Patent: WO2010/19511, 2010, A2. Location in patent: Page/Page column 125-126
[2] Chemical Communications, 2011, vol. 47, # 15, p. 4439 - 4441
[3] Patent: CN104274839, 2017, B. Location in patent: Paragraph 0036; 0038; 0040; 0041
[4] Angewandte Chemie - International Edition, 2009, vol. 48, # 11, p. 2024 - 2026
[5] Tetrahedron Letters, 1995, vol. 36, # 27, p. 4733 - 4736
Fmoc-Tyr-OtBu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fmoc-Tyr-OtBu manufacturers
- Product
- Fmoc-Tyr-OtBu 133852-23-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12