3-(2-Thienyl)-1-propanol
- Product Name
- 3-(2-Thienyl)-1-propanol
- CAS No.
- 19498-72-7
- Chemical Name
- 3-(2-Thienyl)-1-propanol
- Synonyms
- 3-(Thiophen-2-yl);2-Thiophenepropanol;3-(2-Thienyl)-1-propanol;3-(thiophen-2-yl)propan-1-ol
- CBNumber
- CB71459624
- Molecular Formula
- C7H10OS
- Formula Weight
- 142.22
- MOL File
- 19498-72-7.mol
3-(2-Thienyl)-1-propanol Property
- Boiling point:
- 240℃
- Density
- 1.131
- Flash point:
- 99℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 15.03±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T344543
- Product name
- 3-(2-Thienyl)-1-propanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T344543
- Product name
- 3-(2-Thienyl)-1-propanol
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T344543
- Product name
- 3-(2-Thienyl)-1-propanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- P000527894
- Product name
- 3-(Thiophen-2-yl)propan-1-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- OR953826
- Product name
- 3-(2-Thienyl)-1-propanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
3-(2-Thienyl)-1-propanol Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 36, p. 2236, 1971 DOI: 10.1021/jo00815a008
Synthesis
5928-51-8
19498-72-7
Step 1: Borane methyl sulfide complex (6.4 mL, 12.8 mmol) was slowly added to a solution of 3-(2-thienyl)propionic acid (1.0 g, 6.4 mmol) in tetrahydrofuran (THF, 18 mL), keeping the reaction temperature at 0 °C. The reaction mixture was stirred continuously at 0 °C for 2 h, and then brought to room temperature and continued stirring for 3 h. The reaction mixture was then cooled to room temperature. Upon completion of the reaction, the mixture was cooled to 0 °C and saturated potassium carbonate solution (5 mL) was slowly added to quench the reaction. The aqueous layer was separated and the organic phase was extracted with ethyl acetate (2 x 15 mL) and ether (2 x 15 mL), respectively. All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to afford the target product 3-(2-thienyl)-1-propanol as a colorless oil (1.0 g, 100% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 7.18-7.17 (m, 1H), 6.99-6.96 (m, 1H), 6.87-6.86 (m, 1H), 3.79-3.74 (m, 2H), 3.0 (t, J = 7.6 Hz, 2H), 2.4-1.97 (m, 2H).
References
[1] Patent: WO2011/61214, 2011, A1. Location in patent: Page/Page column 87-88
[2] Patent: WO2008/79382, 2008, A1. Location in patent: Page/Page column 128
[3] Journal of the American Chemical Society, 2015, vol. 137, # 32, p. 10100 - 10103
[4] Patent: US6218538, 2001, B1
3-(2-Thienyl)-1-propanol Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-Thienyl)-1-propanol Suppliers
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View Lastest Price from 3-(2-Thienyl)-1-propanol manufacturers
- Product
- 3-(2-Thienyl)-1-propanol 19498-72-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14