ChemicalBook > CAS DataBase List > 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
- Product Name
- 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
- CAS No.
- 915030-08-9
- Chemical Name
- 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
- Synonyms
- 4-Carboxy-2-(trifluoromethyl)-1,3-thiazole;2-(trifluoroMethyl)thiazole-4-carboxylic acid;4-Thiazolecarboxylic acid, 2-(trifluoromethyl)-;2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;Name 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid
- CBNumber
- CB71466439
- Molecular Formula
- C5H2F3NO2S
- Formula Weight
- 197.14
- MOL File
- 915030-08-9.mol
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2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Property
- Melting point:
- 179-184°C
- Boiling point:
- 224.6±40.0 °C(Predicted)
- Density
- 1.668±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 3.09±0.10(Predicted)
- color
- Gray
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 775169
- Product name
- 2-(Trifluoromethyl)thiazole-4-carboxylic acid
- Purity
- 95% (GC)
- Packaging
- 500mg
- Price
- $81.6
- Updated
- 2023/06/20
TRC
- Product number
- T797208
- Product name
- 2-(Trifluoromethyl)thiazole-4-carboxylic acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- T797208
- Product name
- 2-(Trifluoromethyl)thiazole-4-carboxylic acid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
TRC
- Product number
- T797208
- Product name
- 2-(Trifluoromethyl)thiazole-4-carboxylic acid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 8H21-3-09
- Product name
- 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
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2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
133046-46-5
915030-08-9
The general procedure for the synthesis of 2-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid from ethyl 2-(trifluoromethyl)thiazole-4-carboxylate was as follows: ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (400 mg, 1.176 mmol) was dissolved in a solvent mixture of THF/methanol (9:1, v/v), and a 1 M aqueous lithium hydroxide (3.55 mL, 3.55 mmol). The reaction mixture was stirred at room temperature for 1 h, followed by adjusting the pH with dilute hydrochloric acid to 2. The reaction mixture was extracted three times with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to dryness under reduced pressure. The product yield was 93% and mass spectrometric detection showed m/z [M+H]+ of 197.1.
References
[1] Patent: WO2011/51540, 2011, A1. Location in patent: Page/Page column 140-141
[2] Patent: WO2006/122200, 2006, A1. Location in patent: Page/Page column 44
[3] Patent: US2009/131431, 2009, A1. Location in patent: Page/Page column 148
[4] Patent: WO2007/36733, 2007, A1. Location in patent: Page/Page column 222-223
[5] Patent: WO2009/147188, 2009, A1. Location in patent: Page/Page column 110
2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID manufacturers
Career Henan Chemical Co
- Product
- Name 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid 915030-08-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09