ChemicalBook > CAS DataBase List > (2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)

(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)

Product Name: (2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)
CAS No.: 108783-02-4
Chemical Name: (2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)
Synonyms: Phostel;5' PHOSPHORYLATING I AMIDITE;Chemical Phosphorylation Reagent;Chemical Phosphorylation Reagent I;Chemical phosphorylating reagent (cpr);2-O-DMT-sulfonyldiethanol phosphoramidite;(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOP;2-[2-(4,4'-Dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-Phosphoramidite;(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE);2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite
CBNumber: CB71476412
Molecular Formula: C34H45N2O7PS
Formula Weight: 656.77
MOL File: 108783-02-4.mol

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(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE) Property

storage temp.: 2-8°C, stored under nitrogen
form: Liquid
color: Colorless to light yellow
Appearance: colorless semisolid
InChIKey: RJDYWMSSNMDIOO-UHFFFAOYSA-N
SMILES: P(N(C(C)C)C(C)C)(OCCS(CCOC(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)(=O)=O)OCCC#N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE) Chemical Properties,Usage,Production

Description

Chemical phosphorylation reagent for the synthesis of 5’-phosphorylated oligonucleotides. The reagent contains a DMT group in its structure, which allows oligonucleotide purification on C18-cartridges or by reversed-phase chromatography. To yield 5’-phosphorylated oligonucleotide, remove DMT group and then deprotect the phosphate group with diluted ammonium solution (0.1 M). Deprotection of the phosphate group is rapid and efficient even under mild basic conditions, so this reagent can be used for DMT-Off synthesis, for example for RNA synthesis, or with dye phosphoramidites that require mild deprotection conditions.

Diluent: anhydrous acetonitrile. Add the diluent to the recommended concentration (0.1 M) and wait until reagent dissolution is complete while mixing periodically. This reagent is viscous amorphous, and it may take up to 10 minutes to dissolve it. Store the diluted reagent in anhydrous conditions for not more than 24 hours.

Coupling: 6 minutes

Uses

2-O-DMT-Sulfonyldiethanol phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

Definition

ChEBI: Beta-D-xylose is d-Xylopyranose in which the anomeric configuration is beta.

(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE) Preparation Products And Raw materials

Raw materials

Preparation Products

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108783-02-4, (2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)Related Search:

DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*

(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE)

Phostel

2-[2-(4,4'-Dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-Phosphoramidite

Chemical Phosphorylation Reagent

5' PHOSPHORYLATING I AMIDITE

Chemical Phosphorylation Reagent I

Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl]sulfonyl]ethyl 2-cyanoethyl ester

2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

2-O-DMT-sulfonyldiethanol phosphoramidite

(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOP

3-[2-[2-[bis(4-methoxyphenyl)-phenyl-methoxy]ethylsulfonyl]ethoxy-(diisopropylamino)phosphanyl]oxypropanenitrile

Chemical phosphorylating reagent (cpr)

108783-02-4

Phosphoramidite