5-BROMO-3-HYDROXYBENZALDEHYDE

Product Name: 5-BROMO-3-HYDROXYBENZALDEHYDE
CAS No.: 199177-26-9
Chemical Name: 5-BROMO-3-HYDROXYBENZALDEHYDE
Synonyms: 109717;3-Bromo-5-hydroxybenzaL;Benzaldehyde, 3-bromo-5-hydroxy-
CBNumber: CB71484895
Molecular Formula: C7H5BrO2
Formula Weight: 201.02
MOL File: 199177-26-9.mol

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5-BROMO-3-HYDROXYBENZALDEHYDE Property

Melting point:: 134-138 °C
Boiling point:: 292.0±20.0 °C(Predicted)
Density: 1.737±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 8.28±0.10(Predicted)
color: Red

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B700675
Product name: 3-Bromo-5-hydroxybenzaldehyde
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W005146
Product name: 3-Bromo-5-hydroxybenzaldehyde
Purity: 99.68%
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: X5196
Product name: 3-bromo-5-hydroxybenzaldehyde
Packaging: 1g
Price: $137
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2615-9-0A
Product name: 3-Bromo-5-hydroxybenzaldehyde
Packaging: 1g
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-W005146
Product name: 3-Bromo-5-hydroxybenzaldehyde
Purity: 99.68%
Packaging: 5g
Price: $210
Updated: 2021/12/16

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5-BROMO-3-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

626-41-5

68-12-2

199177-26-9

Step-1: Synthesis of 3-bromo-5-hydroxybenzaldehyde: 2.5 M n-butyllithium (n-BuLi, 7.9 mL, 19.84 mmol) was slowly added dropwise to a solution of 3,5-dibromophenol (2.5 g, 9.92 mmol) in tetrahydrofuran (THF, 25 mL) at -78°C for a controlled time of 15 min. The reaction mixture was continued to be stirred at -78 °C for 20 min, followed by dropwise addition of dry N,N-dimethylformamide (DMF, 15.29 mL, 198.4 mmol). After maintaining the reaction at -78 °C for 30 min, the reaction mixture was warmed up to room temperature and stirred for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (200 mL) and extracted with ethyl acetate (EtOAc, 3 x 250 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (100-200 mesh, eluent: 0-6% hexane solution of ethyl acetate) to afford the target compound 3-bromo-5-hydroxybenzaldehyde (1.0 g, 50.12% yield) as a white solid. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ (ppm): 10.5 (broad peak, 1H), 9.85 (single peak, 1H), 7.50 (single peak, 1H), 7.25 (double peak, 2H).

References

[1] Patent: WO2015/184405, 2015, A1. Location in patent: Paragraph 0135; 0141; 0148; 0154; 0160; 0166; 0173; 0184
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 49, p. 15746 - 15750
[3] Angew. Chem., 2017, vol. 129, p. 15952 - 15957,6
[4] Patent: WO2018/114965, 2018, A1. Location in patent: Page/Page column 26
[5] Patent: WO2008/58387, 2008, A1. Location in patent: Page/Page column 20

5-BROMO-3-HYDROXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-3-HYDROXYBENZALDEHYDE Suppliers

China 76 India 3 United Kingdom 2 United States 7 Global 88

Energy Chemical

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View Lastest Price from 5-BROMO-3-HYDROXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-BROMO-3-HYDROXYBENZALDEHYDE 199177-26-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-24

Henan Bao Enluo International TradeCo.，LTD

Product: 5-BROMO-3-HYDROXYBENZALDEHYDE 199177-26-9
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-08-10

Career Henan Chemical Co

Product: 5-BROMO-3-HYDROXYBENZALDEHYDE 199177-26-9
Price: US $9.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

199177-26-9, 5-BROMO-3-HYDROXYBENZALDEHYDERelated Search:

3-Bromo-5-ethoxy-4-hydroxybenzaldehyde Disperse Blue 81 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE Disperse Blue 56 2,3-DIBROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE 5-Bromovanillin 7-Bromobenzo[1,3]dioxole-5-carbaldehyde 1-Amino-2-bromo-4-hydroxy-9,10-anthraquinone 3-BROMO-5-METHOXYBENZOIC ACID 2,3-DIBROMO-4,5-DIHYDROXYBENZALDEHYDE 5-BROMOVERATRALDEHYDE 4-Bromo-6,7-dimethoxyindanone 2,3-DIBROMO-5-ETHOXY-6-HYDROXYBENZALDEHYDE 3-BROMO-2-HYDROXY-5-METHOXYBENZALDEHYDE 5-BROMO-3-ETHOXY-2-HYDROXYBENZALDEHYDE 5-BROMOPROTOCATECHUALDEHYDE (4-BROMO-2-FORMYL-6-METHOXY-PHENOXY)-ACETIC ACID ETHYL ESTER 3-BROMO-4,5-DIMETHOXYBENZOIC ACID

109717

3-Bromo-5-hydroxybenzaL

Benzaldehyde, 3-bromo-5-hydroxy-

199177-26-9

Aromatic Aldehydes & Derivatives (substituted)