2-(4-BROMO-PHENYL)-PYRROLIDINE
- Product Name
- 2-(4-BROMO-PHENYL)-PYRROLIDINE
- CAS No.
- 383127-22-8
- Chemical Name
- 2-(4-BROMO-PHENYL)-PYRROLIDINE
- Synonyms
- MFCD11506298;AKOS BB-8866;2-(4-BROMO-PHENYL)-PYRROLIDINE;Pyrrolidine, 2-(4-bromophenyl)-;4-(Pyrrolidin-3-yl)bromobenzene;2-(4-Bromo-phenyl)-pyrrolidine 97%;1-Bromo-4-(pyrrolidin-2-yl)benzene;2-(4-BROMOPHENYL)PYRROLIDINE HYDROCHLORIDE;tert-butyl 3-allyl-3-hydroxyazetidine-10-carboxylate;methyl (R)-2-amino-3-(naphthalen-1-yl)propanoate hydrochloride
- CBNumber
- CB7148677
- Molecular Formula
- C10H12BrN
- Formula Weight
- 226.11
- MOL File
- 383127-22-8.mol
2-(4-BROMO-PHENYL)-PYRROLIDINE Property
- Boiling point:
- 287.2±33.0 °C(Predicted)
- Density
- 1.369±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.58±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C10H12BrN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2
- InChIKey
- HIJZBROSVFKSCP-UHFFFAOYSA-N
- SMILES
- N1CCCC1C1=CC=C(Br)C=C1
- CAS DataBase Reference
- 383127-22-8(CAS DataBase Reference)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B6495
- Product name
- 2-(4-Bromophenyl)pyrrolidine
- Purity
- min. 95.0 %
- Packaging
- 200MG
- Price
- $54
- Updated
- 2025/07/31
- Product number
- B6495
- Product name
- 2-(4-Bromophenyl)pyrrolidine
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $162
- Updated
- 2025/07/31
- Product number
- B804400
- Product name
- 2-(4-Bromophenyl)pyrrolidine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B804400
- Product name
- 2-(4-Bromophenyl)pyrrolidine
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- FB50842
- Product name
- 2-(4-Bromophenyl)pyrrolidine
- Packaging
- 5G
- Price
- $660
- Updated
- 2021/12/16
2-(4-BROMO-PHENYL)-PYRROLIDINE Chemical Properties,Usage,Production
Synthesis
22217-79-4
383127-22-8
General procedure for the synthesis of 2-(4-bromophenyl)-pyrrolidine from 5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole: NaBH4 (1.52 g, 40 mmol) was added to 5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole (4.48 g, 20 mmol) dissolved in a H2O/MeOH (30 mL, v /v 1:4) solution. The reaction mixture was stirred for 4 hours and then slowly warmed up to room temperature. After the completion of the reaction was monitored by TLC, 2N HCl was added to quench the unreacted NaBH4. Subsequently, the organic and aqueous layers were separated by diluting the reaction mixture with deionized water and ether. The aqueous layer was further extracted with ether and the combined organic phases were adjusted to pH 12-13 with 4 M NaOH and washed with ethyl acetate. All organic extracts were combined, washed with saturated brine and dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure to give the crude product 2-(4-bromophenyl)-pyrrolidine as a yellow oil (3.8 g, 84% yield), which could be used in the subsequent reaction without further purification.LC-MS (ESI) m/z: 226 (M + 1)+.
References
[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 99
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 196
[3] Journal of Organic Chemistry, 2005, vol. 70, # 9, p. 3705 - 3708
[4] Patent: WO2008/70447, 2008, A2. Location in patent: Page/Page column 49
[5] Patent: WO2009/112565, 2009, A1. Location in patent: Page/Page column 42
2-(4-BROMO-PHENYL)-PYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-BROMO-PHENYL)-PYRROLIDINE manufacturers
- Product
- 2-(4-BROMO-PHENYL)-PYRROLIDINE 383127-22-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08