ChemicalBook > CAS DataBase List > ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE

ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE

Product Name
ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
CAS No.
101667-98-5
Chemical Name
ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
Synonyms
5-Methyl-4-chloro-6-ethoxycarbonylthieno<2,3-d>pyrimidine;4-Chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester;Thieno[2,3-d]pyrimidine-6-carboxylic acid, 4-chloro-5-methyl-, ethyl ester
CBNumber
CB71492278
Molecular Formula
C10H9ClN2O2S
Formula Weight
256.71
MOL File
101667-98-5.mol
More
Less

ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE Property

Melting point:
114-115 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
Boiling point:
374.4±37.0 °C(Predicted)
Density 
1.409
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-0.01±0.40(Predicted)
More
Less

Safety

HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
E903808
Product name
Ethyl4-Chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
Packaging
100mg
Price
$90
Updated
2021/12/16
TRC
Product number
E903808
Product name
Ethyl4-Chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
Packaging
50mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
0435AA
Product name
Ethyl4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
Packaging
5g
Price
$779
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0026050
Product name
ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$852.55
Updated
2021/12/16
Matrix Scientific
Product number
143591
Product name
Ethyl 4-chloro-5-methylthieno-[2,3-d]pyrimidine-6-carboxylate
Purity
95%
Packaging
5g
Price
$1074
Updated
2021/12/16
More
Less

ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

17417-67-3

101667-98-5

Ethyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-D]-pyrimidine-6-carboxylate (425 mg, 1.783 mmol) was used as a starting material, and after dissolution in toluene (8 mL), N,N-diisopropylethylamine (DIPEA, 248 μL, 1.426 mmol, 0.8 eq.) and phosphorus oxychloride (POCl3, 199 μ L, 2.14 mmol, 1.2 equiv). The reaction mixture was heated to reflux in an oil bath at 120-125°C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into a mixed system of ice-cooled saturated aqueous sodium bicarbonate (20 mL) and ethyl acetate (EtOAc, 50 mL) with rapid stirring to thoroughly quench the excess of phosphorous trichloride. The organic and aqueous phases were separated and the organic phase was washed once more with saturated aqueous sodium bicarbonate (20 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford ethyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (25B) as a yellow solid (432 mg, 94% yield).

References

[1] Patent: WO2005/42537, 2005, A1. Location in patent: Page/Page column 57
[2] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 148 - 160
[3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 9, p. 1663 - 1669
[4] Pharmazie, 1993, vol. 48, # 3, p. 192 - 194
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985, vol. 21, # 7, p. 767 - 770

ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE Suppliers

China 26 India 1 Switzerland 1 Ukraine 2 United Kingdom 2 United States 5 Global 37
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Nantong Bosu Pharmaceutical Technology Co., Ltd.
Tel
0513-0513-51005092 13390947892
Fax
0513-51005092
Email
tashiyxy@163.com
Country
China
ProdList
839
Advantage
58
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1707
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Blocksynth Pharmaceutical Technology Co.,Ltd
Tel
0086-19817745290; +8619817745290
Email
bd@blocksynth.com
Country
China
ProdList
5661
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-86838766 13636419861
Email
2258830676@qq.com
Country
China
ProdList
5044
Advantage
58
Shanghai Amico Chemicals Co. LTD
Tel
微信 17321281695 18019252918
Fax
qq:1454668768
Email
1454668768@qq.com
Country
China
ProdList
14856
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Hefei Mokai Pharmaceutical Technology Co., Ltd
Tel
18130062233
Email
3362556465@qq.com
Country
China
ProdList
8100
Advantage
58
Henan Evonik Biotechnology Co. LTD
Tel
15672878902
Email
hnyingchuang@163.com
Country
China
ProdList
3905
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
Ningbo Zhenyue Pharmaceutical Technology Co., Ltd
Tel
19817745290
Email
bd@blocksynth.com
Country
China
ProdList
5869
Advantage
58
Nanjing Hongwang Pharmaceutical Technology Co., Ltd
Tel
15366073145
Email
3016wan@163.com
Country
China
ProdList
623
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Coresyn Pharmatech Co., Ltd.
Tel
+86-571-86626709 +86-18157142896
Email
cbc@coresyn.com
Country
China
ProdList
9984
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Beijing ALFCHEM Science Co.,Ltd.
Tel
--
Fax
--
Country
China
ProdList
6456
Advantage
30

101667-98-5, ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATERelated Search:

Oxalyl chloride 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE ETHYL 4-CHLORO-2-(CHLOROMETHYL)-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 2-([(4-BROMOPHENYL)THIO]METHYL)-4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE 2-METHOXYETHYL 4-CHLORO-5-METHYL-2-PYRIDIN-3-YLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2-(2-METHOXYBENZYL)-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2-([(4-CHLOROPHENYL)THIO]METHYL)-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2-[(DIMETHYLAMINO)METHYL]-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-5-METHYL-2-(PIPERIDIN-1-YLMETHYL)THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2-([(2-CYANOETHYL)THIO]METHYL)-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-5-METHYL-2-(MORPHOLIN-4-YLMETHYL)THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2,5-DIMETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-5-METHYL-2-[(PHENYLTHIO)METHYL]THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE

  • 4-Chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
  • 5-Methyl-4-chloro-6-ethoxycarbonylthieno<2,3-d>pyrimidine
  • Thieno[2,3-d]pyrimidine-6-carboxylic acid, 4-chloro-5-methyl-, ethyl ester
  • 101667-98-5