2-Chloro-3-pyridineacetic acid
Physical Form- Product Name
- 2-Chloro-3-pyridineacetic acid
- CAS No.
- 61494-55-1
- Chemical Name
- 2-Chloro-3-pyridineacetic acid
- Synonyms
- 2-(2-chloropyridin-3-yl)acetic acid;2-(2-chloropyridin-3-yl)acetic;2-Chloro-3-pyridineacetic acid;2-Chloropyridine-3-acetic acid;(2-Chloro-3-pyridyl)acetic Acid;3-Pyridineacetic acid, 2-chloro-;2-(2-chloro-3-pyridyl)acetic acid;2-(2-Chloropyridin-3-yl)aceticaci;2-CHLORO-PYRIDINE-3-YL-ACETIC ACID;3-(Carboxymethyl)-2-chloropyridine
- CBNumber
- CB71501293
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 61494-55-1.mol
2-Chloro-3-pyridineacetic acid Property
- Melting point:
- 203-204 °C(Solv: benzene (71-43-2))
- Boiling point:
- 336.6±27.0 °C(Predicted)
- Density
- 1.405±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.79±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H6ClNO2/c8-7-5(4-6(10)11)2-1-3-9-7/h1-3H,4H2,(H,10,11)
- InChIKey
- NOASBJYTBZMVKT-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1CC(O)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B405235
- Product name
- 2-(2-Chloropyridin-3-yl)aceticAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y5005
- Product name
- 2-Chloro-3-pyridineaceticacid
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- 4H21-5-0A
- Product name
- (2-Chloropyridin-3-yl)acetic acid
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- HCH0357716
- Product name
- 2-CHLORO-3-PYRIDINEACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.31
- Updated
- 2021/12/16
- Product number
- A145012
- Product name
- 2-(2-Chloropyridin-3-yl)aceticacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $33
- Updated
- 2021/12/16
2-Chloro-3-pyridineacetic acid Chemical Properties,Usage,Production
Physical Form
Solid
Uses
2-(2-Chloropyridin-3-yl)acetic Acid can be prepared to use as RORγ agonists for the treatment of cancer.
Synthesis
101012-32-2
61494-55-1
General procedure for the synthesis of 2-chloropyridine-3-acetic acid from (2-chloropyridin-3-yl)acetonitrile: 15% w/w NaOH solution (15 mL) was added to (2-chloropyridin-3-yl)acetonitrile (0.932 g, 6.1 mmol). The reaction mixture was heated to reflux for 35 min and subsequently cooled to room temperature. The mixture was further cooled to 0 °C and acidified to pH 1 with concentrated hydrochloric acid (about 5 mL of hydrochloric acid was required). The resulting suspension was allowed to stand in an ice bath for 1 hour. The precipitate was collected by filtration and washed with cold isopropanol (3 x 15 mL) to afford 2-chloropyridine-3-acetic acid (1.05 g, 100% yield) as an off-white solid.1H NMR (400 MHz, d6-DMSO) δ 12.63 (s, 1H), 8.32 (dd, J = 4.8, 1.9 Hz, 1H), 7.86 (dd, J = 7.5, 1.9 Hz, 1H). 1.9 Hz, 1H), 7.41 (dd, J = 7.5, 4.8 Hz, 1H), 3.75 (s, 2H).LCMS Method C: Retention time 4.06 min; m/z 172 [M+H]+.
References
[1] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 138; 139
[2] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 141
[3] Patent: WO2009/13462, 2009, A1. Location in patent: Page/Page column 26
[4] Patent: WO2009/93008, 2009, A1. Location in patent: Page/Page column 25-26
[5] Patent: WO2009/153554, 2009, A1. Location in patent: Page/Page column 36
2-Chloro-3-pyridineacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-pyridineacetic acid manufacturers
- Product
- 2-CHLORO-3-PYRIDINEACETIC ACID 61494-55-1
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-30
- Product
- 2-Chloro-3-pyridineacetic acid 61494-55-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07
- Product
- 2-Chloro-3-pyridineacetic acid 61494-55-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-14