N-(4-Fluorobenzoyl)-L-proline

Product Name: N-(4-Fluorobenzoyl)-L-proline
CAS No.: 62522-93-4
Chemical Name: N-(4-Fluorobenzoyl)-L-proline
Synonyms: -1-(4-Fluorobenzoyl);1-(4-Fluorobenzoyl)-L-Proline;N-(4-Fluorobenzoyl)-L-proline;L-Proline, 1-(4-fluorobenzoyl)-;1-(4-fluorbenzoyl)-pyrrolidine-2-carboxylic acid;(S)-1-(4-Fluorobenzoyl)pyrrolidine-2-carboxylic acid;(2S)-1-(4-fluorobenzoyl)pyrrolidine-2-carboxylic acid
CBNumber: CB71501662
Molecular Formula: C12H12FNO3
Formula Weight: 237.23
MOL File: 62522-93-4.mol

More

Less

N-(4-Fluorobenzoyl)-L-proline Property

Boiling point:: 441.6±40.0 °C(Predicted)
Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.29±0.10(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Activate Scientific

Product number: AS42173
Product name: (S)-1-(4-Fluorobenzoyl)pyrrolidine-2-carboxylic acid
Purity: 98+% ee
Packaging: 1g
Price: $151
Updated: 2021/12/16

AK Scientific

Product number: 9426AB
Product name: (S)-1-(4-Fluorobenzoyl)pyrrolidine-2-carboxylicacid
Packaging: 1g
Price: $157
Updated: 2021/12/16

AK Scientific

Product number: 9426AB
Product name: (S)-1-(4-Fluorobenzoyl)pyrrolidine-2-carboxylicacid
Packaging: 5g
Price: $311
Updated: 2021/12/16

Activate Scientific

Product number: AS42173
Product name: (S)-1-(4-Fluorobenzoyl)pyrrolidine-2-carboxylic acid
Purity: 98+% ee
Packaging: 5G
Price: $353
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0010324
Product name: 1-(4-FLUOROBENZOYL)-L-PROLINE
Purity: 95.00%
Packaging: 5MG
Price: $500.08
Updated: 2021/12/16

More

Less

N-(4-Fluorobenzoyl)-L-proline Chemical Properties,Usage,Production

Synthesis

403-43-0

147-85-3

62522-93-4

The general procedure for the synthesis of N-(4-fluorobenzoyl)-L-proline from 4-fluorobenzoyl chloride and L-proline was as follows: L-proline (2.5 g, 22 mmol) was dissolved in 5% NaOH solution (25 mL, 31 mmol), cooled to the appropriate temperature, and then 4-fluorobenzoyl chloride (3.17 g, 20 mmol) was slowly added dropwise under vigorous stirring. The reaction mixture was then supplemented with 5% NaOH solution (15 mL, 19 mmol) and stirred continuously for 1 hour at room temperature. After completion of the reaction, the mixture was cooled in an ice bath and the pH was adjusted to acidic by slowly adding 20% HCl solution (10 mL) until crystals were precipitated. The resulting crystals were filtered, washed with cold water and then dried in a desiccator using P2O5 as the drying agent. Finally, 4.21 g of N-(4-fluorobenzoyl)-L-proline crystals were obtained in 89% yield (based on a theoretical value of 88.8%). The product characterization data were as follows: molecular formula C12H12FNO3, molecular weight 237.23; melting point 174.0 °C; IR (NaCl, cm-1): 1735, 1605, 1585, 1514, 1440, 1230, 1180, 1161, 856, 762, 513; 1H NMR (CDCl3, δ, ppm). 7.64-7.61 (d, 2H, J=5.4 Hz), 7.59-7.57 (d, 2H, J=5.4 Hz), 7.16-7.07 (t, 2H, J=8.6 Hz).

References

[1] Patent: EP1246825, 2003, B1. Location in patent: Page 32
[2] Patent: US2003/153558, 2003, A1

N-(4-Fluorobenzoyl)-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(4-Fluorobenzoyl)-L-proline Suppliers

China 22 India 1 United States 3 Global 26

QINGDAO CARELONGPHARMATECH CO.,LTD

Tel: 0532-0532-88191853 13061484198
Fax: +86-532-88191853
Email: sales@carelongchem.com
Country: China
ProdList: 437
Advantage: 57

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

TaiChem Taizhou Limited

Tel: 052386810091
Email: zcwy9518@yeah.net
Country: China
ProdList: 3912
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

More

Less

View Lastest Price from N-(4-Fluorobenzoyl)-L-proline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-(4-Fluorobenzoyl)-L-proline 62522-93-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-14

62522-93-4, N-(4-Fluorobenzoyl)-L-prolineRelated Search:

N-Benzoyl-L-proline 1-(4-Fluorobenzoyl)pyrrolidine N-(4-Fluorobenzoyl)-L-proline

N-(4-Fluorobenzoyl)-L-proline

(S)-1-(4-Fluorobenzoyl)pyrrolidine-2-carboxylic acid

-1-(4-Fluorobenzoyl)

1-(4-fluorbenzoyl)-pyrrolidine-2-carboxylic acid

1-(4-Fluorobenzoyl)-L-Proline

L-Proline, 1-(4-fluorobenzoyl)-

(2S)-1-(4-fluorobenzoyl)pyrrolidine-2-carboxylic acid

62522-93-4

pharmacetical