5-BROMO-6-FLUORO-1H-INDAZOLE
- Product Name
- 5-BROMO-6-FLUORO-1H-INDAZOLE
- CAS No.
- 105391-70-6
- Chemical Name
- 5-BROMO-6-FLUORO-1H-INDAZOLE
- Synonyms
- 5-BroMo-6-fluoro-1H-;5-BROMO-6-FLUOROINDAZOLE;5-BROMO-6-FLUORO-1H-INDAZOLE;1H-Indazole, 5-bromo-6-fluoro-
- CBNumber
- CB71502018
- Molecular Formula
- C7H4BrFN2
- Formula Weight
- 215.02
- MOL File
- 105391-70-6.mol
5-BROMO-6-FLUORO-1H-INDAZOLE Property
- Boiling point:
- 332.2±22.0 °C(Predicted)
- Density
- 1.861
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.95±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C7H4BrFN2/c8-5-1-4-3-10-11-7(4)2-6(5)9/h1-3H,(H,10,11)
- InChIKey
- ZNNFNEIFQIAWNY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Br)C(F)=C2)C=N1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B685938
- Product name
- 5-Bromo-6-fluoro-1H-indazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB105524
- Product name
- 5-bromo-6-fluoro-1h-indazole
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB105524
- Product name
- 5-bromo-6-fluoro-1h-indazole
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- PC402011
- Product name
- 5-Bromo-6-fluoro-1H-indazole
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- FB105524
- Product name
- 5-bromo-6-fluoro-1h-indazole
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
5-BROMO-6-FLUORO-1H-INDAZOLE Chemical Properties,Usage,Production
Uses
5-Bromo-6-fluoro-1H-indazole is used for optimization and biological evaluation of [(trifluoromethyl)phenyl]indazoles as TRPA1 antagonists.
Synthesis
633335-81-6
105391-70-6
General procedure for the synthesis of 5-bromo-6-fluoro-1H-indazole from 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone: 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone (1.58 g, 6.15 mmol) was dissolved in a solvent mixture of a 3M HCl aqueous solution (20 mL) and methanol (4 mL). The reaction mixture was heated to reflux at 90 °C for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the pH was adjusted to 10 with 1 M NaOH aqueous solution. at this point, a colorless solid precipitated from the solution, which was collected by filtration and dried under vacuum to afford the target product 5-bromo-6-fluoro-1H-indazole (1.22 g, 93% yield). The 1H NMR (CDCl3) data of the product were as follows: δ 9.0-10.20 (1H, br), 8.02 (1H, s), 7.97 (1H, d, J = 6.4 Hz), 7.28 (1H, s).
References
[1] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 55
[2] Patent: WO2006/44860, 2006, A2. Location in patent: Page/Page column 37-38
[3] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0619; 0620
[4] Patent: WO2009/32123, 2009, A2. Location in patent: Page/Page column 179-180
[5] Patent: WO2009/32125, 2009, A1. Location in patent: Page/Page column 119
5-BROMO-6-FLUORO-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-6-FLUORO-1H-INDAZOLE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5-BROMO-6-FLUORO-1H-INDAZOLE manufacturers
- Product
- 5-BROMO-6-FLUORO-1H-INDAZOLE 105391-70-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-BROMO-6-FLUORO-1H-INDAZOLE 105391-70-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-BROMO-6-FLUORO-1H-INDAZOLE 105391-70-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04