5-METHOXY-NICOTINIC ACID
- Product Name
- 5-METHOXY-NICOTINIC ACID
- CAS No.
- 20826-03-3
- Chemical Name
- 5-METHOXY-NICOTINIC ACID
- Synonyms
- 5-Methoxynicotinic acid;5-methoxypyridine-3-carboxylicaci;3-Methoxypyridine-5-carboxylic acid;3-Methoxy-5-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 5-methoxy-;5-Methoxypyridine-3-carboxylic acid, 3-Carboxy-5-methoxypyridine
- CBNumber
- CB71502740
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 20826-03-3.mol
5-METHOXY-NICOTINIC ACID Property
- Melting point:
- 127-131°C
- Boiling point:
- 330.9±22.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 2.08±0.10(Predicted)
- color
- Off-white to light grey
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M264938
- Product name
- 5-MethoxynicotinicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR16421
- Product name
- 5-Methoxynicotinicacid
- Packaging
- 250mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 4H21-1-Q8
- Product name
- 5-Methoxynicotinic acid
- Packaging
- 250mg
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 4H21-1-Q8
- Product name
- 5-Methoxynicotinic acid
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- W4373
- Product name
- 5-methoxynicotinicacid
- Packaging
- 10g
- Price
- $377
- Updated
- 2021/12/16
5-METHOXY-NICOTINIC ACID Chemical Properties,Usage,Production
Synthesis
29681-46-7
20826-03-3
General procedure for the synthesis of 5-methoxynicotinic acid from methyl 5-methoxypyridine-3-carboxylate: 2 M aqueous NaOH solution (3 mL) was added to a mixed solution of THF (4 mL) and methanol (4 mL) containing methyl 5-methoxynicotinate (300 mg, 1.79 mmol). The reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with distilled water (20 mL) and the pH of the aqueous phase was subsequently adjusted to 6 with 2 M aqueous HCl. The aqueous phase was extracted with dichloromethane (20 mL x 3), the organic phases were combined and washed with saturated saline (10 mL x 2), dried over anhydrous sodium sulfate, and concentrated to give the title compound, 5-methoxynicotinic acid, as a white solid (230 mg, 84% yield).LC-MS analysis Results: retention time 0.36 min; m/z 154.1 [M+H]+.
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3168 - 3185
[2] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 125-126
5-METHOXY-NICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXY-NICOTINIC ACID manufacturers
- Product
- 5-METHOXY-NICOTINIC ACID 20826-03-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-11