Istaroxime

Product Name: Istaroxime
CAS No.: 203737-93-3
Chemical Name: Istaroxime
Synonyms: CS-1089;PST2744;PST 2744;PST-2744;Debio0614;Debio 0614;Istaroxime;PST2744/PST-2744;Istaroxime(PST2744);PST2744; PST 2744; ISTAROXIME; DEBIO 0614; DEBIO0614
CBNumber: CB71508601
Molecular Formula: C21H32N2O3
Formula Weight: 360.5
MOL File: 203737-93-3.mol

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Istaroxime Property

Boiling point:: 511.1±60.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in H2O
form: Powder
pka: 9.49±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3507
Product name: Istaroxime
Packaging: 2mg
Price: $227
Updated: 2021/12/16

ApexBio Technology

Product number: A3507
Product name: Istaroxime
Packaging: 5mg
Price: $340
Updated: 2021/12/16

ApexBio Technology

Product number: A3507
Product name: Istaroxime
Packaging: 10mg
Price: $520
Updated: 2021/12/16

ApexBio Technology

Product number: A3507
Product name: Istaroxime
Packaging: 50mg
Price: $1457
Updated: 2021/12/16

DC Chemicals

Product number: DC7151
Product name: Istaroxime(PST2744)
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

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Istaroxime Chemical Properties,Usage,Production

Biological Activity

istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (na+/k+ atpase). istaroxime is an investigational drug originally patented and developed by the italian pharmaceutical company sigma-tau. istaroxime is now under development for treatment of acute decompensated heart failure by cvie therapeutics.

in vitro

pst2744 inhibited the na+/k+-atpase activity from dog kidney with an ic50 value of 0.43 ± 0.15 μm [1]. the transient inward current (i(ti)) induced by a ca(2+) transient in the presence of complete na(+)/k(+) pump blockade was inhibited (-43%) by pst2744 but not by digoxin [2].

in vivo

intravenous infusion of 0.2 mg/kg/min pst2744 in anesthetized guinea pigs exerted an immediate and long-lasting inotropic effect (ed(80) of 1.89 +/- 0.37 mg/kg) without causing lethal arrhythmias up to a cumulative dose of 18 mg/kg [1]. istaroxime intravenous infusion (0.11 mg/kg per min) significantly increased both indices of contraction and relaxation (fractional shortening, +18+/-3.7%; aortic flow rate, +19+/-2.9%; peak myocardial systolic velocity, +36+/-7%; circumferential fiber shortening, +24+/-4.1%; peak atrial flow velocity, +69+/-8.6%; isovolumic relaxation time, +19+/-6.9%; and peak myocardial early diastolic velocity, +42+/-12%) [3]. in 5 animals, pst-2744 effects were compared with dobutamine. heart rates, pr intervals and qt intervals were unchanged following pst-2744 administration. pst-2744 increased contractility (+dp/dt) by 56% from 1881 +/- 282 mm hg/s to 2939 +/- 734 mm hg/s (p < 0.01) [4].

IC 50

0.43 ± 0.15 μm (na+/k+-atpase activity from dog kidney) [1]

Istaroxime Preparation Products And Raw materials

Raw materials

Preparation Products

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Istaroxime Suppliers

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View Lastest Price from Istaroxime manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Istaroxime 203737-93-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Istaroxime 203737-93-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

203737-93-3, IstaroximeRelated Search:

Istaroxime

PST 2744

PST2744

PST-2744

PST2744/PST-2744

CS-1089

Istaroxime(PST2744)

(3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione

Debio 0614

Debio0614

PST2744; PST 2744; ISTAROXIME; DEBIO 0614; DEBIO0614

Androstane-3,6,17-trione, 3-[O-(2-aminoethyl)oxime], (5α)-

203737-93-3