3-iodo-1H-pyrrolo[3,2-b]pyridine

Uses

Product Name: 3-iodo-1H-pyrrolo[3,2-b]pyridine
CAS No.: 1083181-26-3
Chemical Name: 3-iodo-1H-pyrrolo[3,2-b]pyridine
Synonyms: 3-Iodo-4-azaindole;3-iodo-1H-pyrrolo[3,2-b]pyridine;1H-Pyrrolo[3,2-b]pyridine, 3-iodo-
CBNumber: CB71515784
Molecular Formula: C7H5IN2
Formula Weight: 244.03
MOL File: 1083181-26-3.mol

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3-iodo-1H-pyrrolo[3,2-b]pyridine Property

Boiling point:: 360.7±22.0 °C(Predicted)
Density: 2.082
storage temp.: 2-8°C(protect from light)
pka: 13.16±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C7H5IN2/c8-5-4-10-6-2-1-3-9-7(5)6/h1-4,10H
InChIKey: ZLVQSDNBINQPHB-UHFFFAOYSA-N
SMILES: C12C(I)=CNC1=CC=CN=2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I719600
Product name: 3-Iodo-1H-pyrrolo[3,2-b]pyridine
Packaging: 1mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR321324
Product name: 3-Iodo-1H-pyrrolo[3,2-b]pyridine
Purity: 97%
Packaging: 250mg
Price: $73
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-H-0A
Product name: 3-Iodo-1H-pyrrolo[3,2-b]pyridine
Purity: 97%
Packaging: 250mg
Price: $87
Updated: 2021/12/16

Apolloscientific

Product number: OR321324
Product name: 3-Iodo-1H-pyrrolo[3,2-b]pyridine
Purity: 97%
Packaging: 1g
Price: $163
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-H-0A
Product name: 3-Iodo-1H-pyrrolo[3,2-b]pyridine
Purity: 97%
Packaging: 1g
Price: $192
Updated: 2021/12/16

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3-iodo-1H-pyrrolo[3,2-b]pyridine Chemical Properties,Usage,Production

Uses

3-Iodo-1H-pyrrolo[3,2-B]pyridine is a pyridine derivative that can be used to prepare plasma kallikrein inhibitors.

Synthesis

272-49-1

1083181-26-3

1H-pyrrolo[3,2-b]pyridine (1.94 g, 16.4 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 10 mL). Subsequently, N-iodosuccinimide (NIS, 4.06 g, 18.1 mmol) was added to this solution. The reaction mixture was stirred at room temperature overnight, during which precipitation was observed to be generated. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with a small amount of THF and heptane. The resulting white solid was dried under vacuum to afford the target product 3-iodo-1H-pyrrolo[3,2-b]pyridine (4.1 g, quantitative yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 300 MHz) δ 8.40 (s, 1H), 7.90-7.70 (m, 2H), 7.15 (d, 1H) and LC-MS (retention time 0.41 min; m/z 245 [M+1]+).

References

[1] Patent: WO2011/78984, 2011, A1. Location in patent: Page/Page column 72
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6935 - 6938
[3] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00203
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 14, p. 5129 - 5136
[5] Patent: US2015/94328, 2015, A1. Location in patent: Paragraph 0349; 0350-0352

3-iodo-1H-pyrrolo[3,2-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-iodo-1H-pyrrolo[3,2-b]pyridine Suppliers

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