4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID
- Product Name
- 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID
- CAS No.
- 94994-39-5
- Chemical Name
- 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID
- Synonyms
- Boc-N-Me-GABA;4-[N-Boc-(methylamino)]butanoic acid;Boc-N-methyl-gamma-aminobutyric acid;(Tert-Butoxy)Carbonyl N-Me-Abu(4)-OH;4-(N-BOC-N-METHYL-AMINO)-BUTYRIC ACID;4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID;Butanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-
- CBNumber
- CB71517339
- Molecular Formula
- C10H19NO4
- Formula Weight
- 217.26
- MOL File
- 94994-39-5.mol
4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID Property
- Boiling point:
- 332.5±21.0 °C(Predicted)
- Density
- 1.091±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.70±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B810123
- Product name
- 4-((tert-Butoxycarbonyl)(methyl)amino)butanoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B810123
- Product name
- 4-((tert-Butoxycarbonyl)(methyl)amino)butanoicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 264340
- Product name
- Boc-N-Methyl-gaMMa-aMinobutyric acid
- Packaging
- 250mg
- Price
- $439
- Updated
- 2021/12/16
- Product number
- CHM0121455
- Product name
- 4-([(TERT-BUTOXY)CARBONYL](METHYL)AMINO)BUTANOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $852.55
- Updated
- 2021/12/16
- Product number
- CHM0121455
- Product name
- 4-([(TERT-BUTOXY)CARBONYL](METHYL)AMINO)BUTANOIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID Chemical Properties,Usage,Production
Uses
4-((tert-Butoxycarbonyl)(methyl)amino)butanoic Acid is used in preparation of substituted straight chain spiro derivatives as menin/MLL protein/protein interaction inhibitors useful for treating diseases.
Synthesis
24424-99-5
6976-17-6
94994-39-5
At room temperature, 4-(methylamino)butyric acid hydrochloride (1.00 g, 6.51 mmol) and triethylamine (2.72 mL, 19.5 mmol) were dissolved in dichloromethane (60 mL) and mixed with stirring. Subsequently, di-tert-butyl dicarbonate (1.56 g, 7.16 mmol) was slowly added to the mixture. The reaction mixture was stirred continuously at room temperature for about 72 hours. The reaction progression was monitored by LC-MS to confirm product formation (retention time 4.11 min; m/z 216.2 [M + H]+). Upon completion of the reaction, dichloromethane and water were added for dilution, and the pH of the aqueous layer was adjusted to 4.5-6.0 with 1 M aqueous hydrochloric acid.The organic and aqueous layers were separated, and the organic layer was dried over anhydrous sodium sulfate, filtered, and then concentrated under reduced pressure to afford 4-(tert-butoxycarbonyl(methyl)amino)butyric acid (1.5 g, 100% yield) as a light yellow thick oil.1H NMR (CDCl3) δ: 3.28 (broad peak, 1H), 2.85 (single peak, 3H), 2.35 (triple peak, 2H), 1.84 (triple peak, 2H), 1.46 (single peak, 9H).
References
[1] Patent: WO2010/123766, 2010, A1. Location in patent: Page/Page column 59
[2] Patent: US2009/48147, 2009, A1. Location in patent: Page/Page column 41
[3] Patent: US2003/220341, 2003, A1. Location in patent: Page/Page column 32-33
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1376 - 1392
[5] Patent: EP881220, 1998, A1
4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID manufacturers
- Product
- 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID 94994-39-5
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10
- Release date
- 2024-08-19