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derquantel

Product Name
derquantel
CAS No.
187865-22-1
Chemical Name
derquantel
Synonyms
derquantel;Unii-0L0ugk6oox;2-Deoxoparaherquamide;2-DeoxoparaherquaMide, 2-DeoxoparaherquaMide A, 2-DesoxoparaherquaMide A, PF 00520904, PNU 141962;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
CBNumber
CB71518503
Molecular Formula
C28H37N3O4
Formula Weight
479.61
MOL File
187865-22-1.mol
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derquantel Property

Boiling point:
641.3±55.0 °C(Predicted)
Density 
1.34
storage temp. 
Store at -20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form 
A solid
pka
15.18±0.60(Predicted)
JECFA Number
75
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19441
Product name
Derquantel
Purity
≥98%
Packaging
5mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
19441
Product name
Derquantel
Purity
≥98%
Packaging
25mg
Price
$1280
Updated
2024/03/01
ApexBio Technology
Product number
C4619
Product name
Derquantel
Packaging
25mg
Price
$1381
Updated
2021/12/16
ApexBio Technology
Product number
C4619
Product name
Derquantel
Packaging
5mg
Price
$345
Updated
2021/12/16
AK Scientific
Product number
2982DC
Product name
Derquantel
Packaging
5mg
Price
$436
Updated
2021/12/16
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derquantel Chemical Properties,Usage,Production

Description

Derquantel is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes. A combination of derquantel and the macrocyclic lactone, abamectin , has been found to have synergistic anthelmintic effects against gastrointestinal nematode parasites in sheep.

Uses

Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel isa potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.

Definition

ChEBI: Derquantel is an azaspiro compound.

derquantel Preparation Products And Raw materials

Raw materials

Preparation Products

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derquantel Suppliers

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187865-22-1, derquantelRelated Search:


  • derquantel
  • 2-Deoxoparaherquamide
  • Unii-0L0ugk6oox
  • 2-DeoxoparaherquaMide, 2-DeoxoparaherquaMide A, 2-DesoxoparaherquaMide A, PF 00520904, PNU 141962
  • Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one, 2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, (1'R,5'aS,7'R,8'aS,9'aR)-
  • 187865-22-1
  • C28H37N3O4