8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one

Product Name: 8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one
CAS No.: 147568-66-9
Chemical Name: 8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one
Synonyms: C Motro;CHF 4226;Carmoterol;CarMotelrol;Carmoterol and its intermediates;8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamin...;8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one;8-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)quinolin-2(1H)-one;8-Hydroxy-5-[(R)-1-hydroxy-2-[[(R)-1-methyl-2-(4-methoxyphenyl)ethyl]amino]ethyl]quinolin-2(1H)-one;8-Hydroxy 5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone
CBNumber: CB71518765
Molecular Formula: C21H24N2O4
Formula Weight: 368.43
MOL File: 147568-66-9.mol

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8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one Property

Boiling point:: 649.1±55.0 °C(Predicted)
Density: 1.248
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.68±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007099
Product name: CARMOTEROL
Purity: 95.00%
Packaging: 5MG
Price: $498.01
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35906
Product name: 8-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)quinolin-2(1H)-one
Purity: 95+%
Packaging: 250mg
Price: $700
Updated: 2021/12/16

Matrix Scientific

Product number: 112959
Product name: Carmoterol
Packaging: 1g
Price: $1679
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007099
Product name: CARMOTEROL
Purity: 95.00%
Packaging: 1G
Price: $2040.15
Updated: 2021/12/16

AK Scientific

Product number: Z4176
Product name: 8-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)quinolin-2(1H)-one
Packaging: 1g
Price: $2316
Updated: 2021/12/16

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8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one Chemical Properties,Usage,Production

Uses

Carmoterol is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors[1][2]. Carmoterol can be used for the research of asthma and chronic obstructive pulmonary disease (COPD)[2].

in vivo

Bronchoconstriction is induced in normal guinea-pigs by intravenous administration of graded doses of Acetylcholine (10, 20 and 40 mg/kg) and Histamine (5, 10 and 20 mg/kg) or in actively sensitized animals by Ovalbumin (5 mg/kg). Carmoterol (from 0.3 to 100 pmol) is given by superfusion onto the tracheal mucosa for 5 min before challenge. Carmoterol causes a dose-dependent inhibition of the acetylcholine-induced bronchoconstriction with the ED₅₀ of 16.7 pmol^[2].

Animal Model:	Male Dunkin Hartley guinea-pigs (weighing 360-380 g)^[2]
Dosage:	0.3 to 100 pmol.
Administration:	Given by superfusion (0.01 mL/min) onto the tracheal mucosa for 5 min before challenge.
Result:	Caused a dose-dependent inhibition of the Acetylcholine-induced bronchoconstriction. Was very potent against Histamine and Ovalbumin-induced reaction, being effective already at 1 pmol.

References

[1] Mario Cazzola, et al. β(2) -adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011 May;163(1):4-17. DOI:10.1111/j.1476-5381.2011.01216.x
[2] Giuseppe Rossoni, et al. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. Pulm Pharmacol Ther. 2007;20(3):250-7. DOI:10.1016/j.pupt.2006.01.004

8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one Suppliers

China 28 India 1 Switzerland 1 United Kingdom 1 United States 4 Global 35

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
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BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
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China Kouting Group Limited

Tel: +86 (21) 5811-6473 5811-6475
Fax: +86 (21) 6129-4103
Email: sales@koutingchina.com
Country: China
ProdList: 496
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Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
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LETOPHARM LIMITED

Tel: +86-21-5821 5861
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Email: sales@letopharm.com
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Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
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Email: abel@ycgmp.com
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
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Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
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Wuhai Shuou Technology Co., Ltd.

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Amatek Scientific Co. Ltd.

Tel: 0512-56316828
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147568-66-9, 8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-oneRelated Search:

Tiotropium bromide

CarMotelrol

8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamino]ethyl]-1H-quinolin-2-one

8-Hydroxy 5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone

8-Hydroxy-5-[(R)-1-hydroxy-2-[[(R)-1-methyl-2-(4-methoxyphenyl)ethyl]amino]ethyl]quinolin-2(1H)-one

Carmoterol

CHF 4226

8-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)quinolin-2(1H)-one

8-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-Methoxyphenyl)-1-Methylethyl]aMino]ethyl]-2(1H)-quinolinone CarMoterol

2(1h)-quinolinone, 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-

C Motro

Carmoterol and its intermediates

8-hydroxy-5-[1-hydroxy-2-[2-(4-methoxyphenyl)propan-2-ylamin...

147568-66-9