ChemicalBook > CAS DataBase List > 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid

6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid

Product Name
6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid
CAS No.
137640-84-7
Chemical Name
6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid
Synonyms
Picolinafen free acid;6-(3-(Trifluoromethyl);Picolinafen acid metabolite;Picolinafen (free acid) in Acetonitrile;6-(3-(TrifluoroMethyl)phenoxy)picolinic acid;6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid;6-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-[3-(trifluoromethyl)phenoxy]-
CBNumber
CB71521572
Molecular Formula
C13H8F3NO3
Formula Weight
283.2
MOL File
137640-84-7.mol
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6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid Property

storage temp. 
2-8°C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T790918
Product name
6-(3-(Trifluoromethyl)phenoxy)picolinicAcid
Packaging
500mg
Price
$200
Updated
2021/12/16
TRC
Product number
T790918
Product name
6-(3-(Trifluoromethyl)phenoxy)picolinicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
T790918
Product name
6-(3-(Trifluoromethyl)phenoxy)picolinicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0070162
Product name
6-[3-(TRIFLUOROMETHYL)PHENOXY]-2-PYRIDINECARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$2464.77
Updated
2021/12/16
AK Scientific
Product number
X9997
Product name
6-(3-(Trifluoromethyl)phenoxy)picolinicacid
Packaging
1g
Price
$203
Updated
2021/12/16
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6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid Chemical Properties,Usage,Production

Uses

6-(3-(trifluoromethyl)phenoxy)picolinic acid is a pesticide metabolite that is found from the breakdown of Picolinafen (P436800) and can be traced in our crops and water.

Synthesis

4684-94-0

98-17-9

137640-84-7

To a 500 mL three-necked flask equipped with a thermometer was added N,N-dimethylformamide (DMF, 200 mL), m-trifluoromethylphenol (0.26 mol, 42.2 g), potassium carbonate (0.266 mol, 37.2 g) and 6-chloro-pyridine-2-carboxylic acid (0.2 mol) were added sequentially. Subsequently cuprous chloride (1.0 g) was added and the reaction mixture was heated to 140 °C and kept at this temperature for 6.0 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then the reaction solution was slowly poured into 600 mL of ice water. The pH of the mixture was adjusted with concentrated hydrochloric acid to 3. The precipitate precipitated was collected by filtration, washed with water several times, and dried to give 6-(3-trifluoromethylphenoxy)-2-pyridinecarboxylic acid as a white solid in 75% yield.

References

[1] Patent: CN108530351, 2018, A. Location in patent: Paragraph 0011; 0026; 0028

6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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137640-84-7, 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acidRelated Search:


  • 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid
  • Picolinafen acid metabolite
  • 6-(3-(TrifluoroMethyl)phenoxy)picolinic acid
  • 6-(3-(Trifluoromethyl)
  • Picolinafen free acid
  • 2-Pyridinecarboxylic acid, 6-[3-(trifluoromethyl)phenoxy]-
  • 6-[3-(trifluoromethyl)phenoxy]pyridine-2-carboxylic acid
  • Picolinafen (free acid) in Acetonitrile
  • 137640-84-7