(4-Trifluoromethyl-pyridin-3-yl)-methanol
- Product Name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- CAS No.
- 198401-76-2
- Chemical Name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- Synonyms
- 4-(Trifluoromethyl)-3-pyridinemethanol;3-Pyridinemethanol, 4-(trifluoromethyl)-;(4-Trifluoromethyl-pyridin-3-yl)-methanol
- CBNumber
- CB71554077
- Molecular Formula
- C7H6F3NO
- Formula Weight
- 177.12
- MOL File
- 198401-76-2.mol
(4-Trifluoromethyl-pyridin-3-yl)-methanol Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T899098
- Product name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T899098
- Product name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 8816AH
- Product name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- Packaging
- 100mg
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 8816AH
- Product name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- Packaging
- 250mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- 8816AH
- Product name
- (4-Trifluoromethyl-pyridin-3-yl)-methanol
- Packaging
- 1g
- Price
- $494
- Updated
- 2021/12/16
(4-Trifluoromethyl-pyridin-3-yl)-methanol Chemical Properties,Usage,Production
Synthesis
175204-82-7
198401-76-2
General procedure for the synthesis of (4-trifluoromethyl-3-pyridine)-methanol from 4-trifluoromethylnicotinic acid methyl ester: 0.37 g (9.7 mmol) of lithium aluminum hydride was dissolved in 100 ml of THF and the solution was cooled down to -50 °C. Subsequently, a solution of 2.0 g (9.8 mmol) of methyl 4-trifluoromethylnicotinate dissolved in 30 ml of THF was added slowly and dropwise. The reaction mixture was stirred continuously at -50 °C for 3 h to ensure complete reaction. Upon completion of the reaction, ethyl acetate was added cautiously and stirred briefly before adding water and continuing to stir. The reaction mixture was separated by vacuum filtration and the filtrate was extracted with ethyl acetate. The organic layer obtained by extraction was washed sequentially with water and aqueous sodium chloride solution and subsequently dried with anhydrous magnesium sulfate. The dried solution was distilled under vacuum to remove the solvent, and the residue was purified by silica gel column chromatography (unfolding agent: hexane-ethyl acetate mixed solvent) to finally obtain 0.6 g (35.3% yield) of (4-trifluoromethylpyridin-3-yl)-methanol as a yellow oil. The product was analyzed by 1H-NMR [CDCl3/TMS, δ (ppm)]: 9.00 (1H, s), 8.73 (1H, d), 7.51 (1H, d), 4.95 (2H, s).
References
[1] Patent: EP1364946, 2003, A1. Location in patent: Page/Page column 200-201
[2] Patent: US2005/256004, 2005, A1. Location in patent: Page/Page column 35
[3] Patent: US5756497, 1998, A
(4-Trifluoromethyl-pyridin-3-yl)-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Trifluoromethyl-pyridin-3-yl)-methanol Suppliers
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 021-20960837
- Fax
- 021-20960837
- market@aloespharm.com
- Country
- China
- ProdList
- 1302
- Advantage
- 55
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 0512-0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 12127
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-87782433 18021532344
- Fax
- 025-87782433
- 1345332203@qq.com
- Country
- China
- ProdList
- 4134
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 0519-88298848 18118010980
- Fax
- 0519-85130733
- info@edengenechem.com
- Country
- China
- ProdList
- 736
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 13918479294
- Fax
- -
- xiebenfa@163.com
- Country
- China
- ProdList
- 4090
- Advantage
- 58
- Tel
- 0319-6931777 13930968617
- Fax
- +86-319-6931577
- 630669494@qq.com
- Country
- China
- ProdList
- 1021
- Advantage
- 58
- Tel
- +86-519-83607890 18921087080
- Fax
- +86-519-83607890
- Country
- China
- ProdList
- 346
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +8615838112936
- alfa10@alfachem.cn
- Country
- China
- ProdList
- 12921
- Advantage
- 58
- Tel
- 17321241880
- 485229790@qq.com
- Country
- China
- ProdList
- 1750
- Advantage
- 58
- Tel
- +86-021-021-50872116 +8613122107989
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 13390851206
- Country
- China
- ProdList
- 188
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 19829389091
- Fax
- QQ:399787610
- 399787610@qq.com
- Country
- China
- ProdList
- 2575
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 18992018580 18165105898
- Fax
- QQ:1617857088
- 13608210612@163.com
- Country
- China
- ProdList
- 2985
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 15652467323
- sales@inno-chem.com.cn
- Country
- China
- ProdList
- 8293
- Advantage
- 58
- Tel
- 0371-53370800 18037197114
- 2853031799@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 19929974101 //1144079830; 19929974101
- Fax
- QQ:1144079830
- 1144079830@qq.com
- Country
- China
- ProdList
- 975
- Advantage
- 58
- Tel
- 400-0628126 15697567703
- sales-team@aobchem.com.cn
- Country
- China
- ProdList
- 49999
- Advantage
- 58
- Tel
- 13005928603
- 211017228@qq.com
- Country
- China
- ProdList
- 8277
- Advantage
- 58
- Tel
- 16621224781
- syy@titansci.com
- Country
- China
- ProdList
- 2896
- Advantage
- 58
- Tel
- 029-029-81148929 17791530722
- 1049@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 15811073878
- sales@peking-pharmacy.com
- Country
- China
- ProdList
- 6297
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 33024
- Advantage
- 60
- Tel
- +86-029-86115547 +86-17791676824
- sales@cochemical.com
- Country
- China
- ProdList
- 3952
- Advantage
- 58
- Tel
- +86-0519-8359-8696 +8618018249389
- sales@anikare.com
- Country
- China
- ProdList
- 9941
- Advantage
- 58
- Tel
- +undefined18958062155
- sales@zjgoldpharm.com
- Country
- China
- ProdList
- 5899
- Advantage
- 58