BOC-(4-AMINOPHENYL)ACETIC ACID
- Product Name
- BOC-(4-AMINOPHENYL)ACETIC ACID
- CAS No.
- 81196-09-0
- Chemical Name
- BOC-(4-AMINOPHENYL)ACETIC ACID
- Synonyms
- BOC-4-APH-OH;BOC-APH(4)-OH;BOC-4-APAC-OH;BOC-4-NHPHAC-OH;BOC-(4-AMINOPHENYL)ACETIC ACID;4-(Boc-aMino)phenylacetic acid;4-(T-Butoxycarbonylamino)phenylacetic acid;4-(T-BUTYLOXYCARBONYLAMINO)PHENYLACETIC ACID;4-(tert-Butoxycarbonylamino)benzeneacetic acid;4-(TERT-BUTYLOXYCARBONYLAMINO)-PHENYLACETIC ACID
- CBNumber
- CB7155482
- Molecular Formula
- C13H17NO4
- Formula Weight
- 251.28
- MOL File
- 81196-09-0.mol
BOC-(4-AMINOPHENYL)ACETIC ACID Property
- Melting point:
- 145-147°
- Boiling point:
- 356.3±25.0 °C(Predicted)
- Density
- 1.220±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 4.37±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 265374
- Product name
- Boc-4-aminophenylacetic acid
- Packaging
- 1g
- Price
- $366
- Updated
- 2021/12/16
- Product number
- 042167
- Product name
- Boc-(4-aminophenyl)acetic acid
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- FB49969
- Product name
- Boc-4-aminophenylacetic acid
- Packaging
- 1g
- Price
- $83.6
- Updated
- 2021/12/16
- Product number
- 042167
- Product name
- Boc-(4-aminophenyl)acetic acid
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 065673
- Product name
- {4-[(tert-Butoxycarbonyl)amino]phenyl}aceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
BOC-(4-AMINOPHENYL)ACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder
Synthesis
24424-99-5
1197-55-3
81196-09-0
General method: synthesis of 2-(4-((tert-butoxycarbonyl)amino)phenyl)acetic acid (5). 4-Aminophenylacetic acid (4, 4 g, 26.46 mmol, 1 equiv) was dissolved in a solvent mixture of dioxane (52 mL) and water (52 mL). In a separate vessel, sodium carbonate (2.8 g, 26.42 mmol, 1 eq.) was dissolved in water (25 mL), stirred and cooled in an ice bath. The sodium carbonate solution was added to a solution of 4-aminophenylacetic acid followed by a one-time addition of di-tert-butyl dicarbonate (BOC-anhydride, 6.24 g, 28.59 mmol, 1.1 eq.). The reaction mixture was continued to be stirred at room temperature for 4 hours. After completion of the reaction, the dioxane was removed by distillation under reduced pressure. The cooled aqueous layer was covered with ethyl acetate and acidified with dilute KHSO4 solution to pH 4. Subsequent extraction with ethyl acetate was carried out and the organic layers were combined and purified by column chromatography (eluent ratio of ethyl acetate-hexane-acetic acid in 1:1:1 eluent ratio) to afford the target compound 5 (7.07 g, 94% yield) as a white solid.1H-NMR (300 MHz, CDCl3) The data were as follows: δ 7.29 (d, J = 8.40 Hz, 2H), 7.19 (d, J = 8.47 Hz, 2H), 3.70 (s, 1H), 3.58 (s, 2H), 1.52 (s, 9H).
References
[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 13, p. 2361 - 2370
[2] Molecules, 2017, vol. 22, # 1,
[3] Patent: US6335445, 2002, B1. Location in patent: Page column 86-87
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 1, p. 254 - 263
[5] Patent: WO2014/85545, 2014, A1. Location in patent: Page/Page column 52; 53
BOC-(4-AMINOPHENYL)ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-(4-AMINOPHENYL)ACETIC ACID manufacturers
- Product
- Boc-4-aminophenylaceticacid 81196-09-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14