ChemicalBook > CAS DataBase List > 2-bromo-5-cyanobenzoic acid
2-bromo-5-cyanobenzoic acid
- Product Name
- 2-bromo-5-cyanobenzoic acid
- CAS No.
- 845616-12-8
- Chemical Name
- 2-bromo-5-cyanobenzoic acid
- Synonyms
- 2-bromo-5-cyanobenzoic acid;2-bromo-5-cyanobenozic acid;BENZOIC ACID, 2-BROMO-5-CYANO-
- CBNumber
- CB71557735
- Molecular Formula
- C8H4BrNO2
- Formula Weight
- 226.03
- MOL File
- 845616-12-8.mol
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2-bromo-5-cyanobenzoic acid Property
- Melting point:
- 183-185°
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- color
- yellow
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Safety
- HS Code
- 2916399090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B292840
- Product name
- 2-Bromo-5-cyanobenzoicAcid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
TRC
- Product number
- B292840
- Product name
- 2-Bromo-5-cyanobenzoicAcid
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W019084
- Product name
- 2-Bromo-5-cyanobenzoicacid
- Packaging
- 1g
- Price
- $245
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W019084
- Product name
- 2-Bromo-5-cyanobenzoicacid
- Packaging
- 100mg
- Price
- $66
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W019084
- Product name
- 2-Bromo-5-cyanobenzoicacid
- Packaging
- 250mg
- Price
- $98
- Updated
- 2021/12/16
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2-bromo-5-cyanobenzoic acid Chemical Properties,Usage,Production
Synthesis
99767-45-0
845616-12-8
The general procedure for the synthesis of 2-bromo-5-cyanobenzoic acid from 2-amino-5-cyanobenzoic acid was as follows: tert-butyl nitrite (1.15 ml, 8.63 mmol) was added dropwise over 2 min at 0 °C to a suspension of copper (II) bromide (1.6 g, 7.1 mmol) in acetonitrile (30 ml). Subsequently, 2-amino-5-cyanobenzoic acid (1.0 g, 6.17 mmol) was added in batches over 10 min at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, then brought to room temperature and stirred overnight. After completion of the reaction, half of the solvent was evaporated under reduced pressure. The residue was dissolved in a mixture of 1N HCl (15 ml) and ethyl acetate (30 ml). The organic layer was extracted with 1N NaOH (3 x 10 ml). The aqueous layer was acidified with 2N HCl and a solid was precipitated. The solid was collected by filtration, washed with water and dried under high vacuum at 50°C to give 2-bromo-5-cyanobenzoic acid (0.92 g, 66% yield) as a yellow solid.
References
[1] Patent: WO2005/23260, 2005, A1. Location in patent: Page/Page column 48
[2] Patent: US2005/209241, 2005, A1. Location in patent: Page/Page column 20
2-bromo-5-cyanobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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