ChemicalBook > CAS DataBase List > Retigabine Dihydrochloride

Retigabine Dihydrochloride

Product Name
Retigabine Dihydrochloride
CAS No.
150812-13-8
Chemical Name
Retigabine Dihydrochloride
Synonyms
D 20443;CS-2270;Retigabin.2HCl;Retigabine HCl;Retigabine 2HCL;Retigabine DiHCl;D20443 dihydrochloride;D-20443 dihydrochloride;D 20443 dihydrochloride;Retigabine Dihydrochloride
CBNumber
CB71565451
Molecular Formula
C16H20Cl2FN3O2
Formula Weight
376.2
MOL File
150812-13-8.mol
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Retigabine Dihydrochloride Property

Melting point:
168-170°C
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BR164335
Product name
Retigabine dihydrochloride
Packaging
10mg
Price
$126
Updated
2021/12/16
ApexBio Technology
Product number
A3758
Product name
Retigabinedihydrochloride
Packaging
50mg
Price
$191
Updated
2021/12/16
Biosynth Carbosynth
Product number
BR164335
Product name
Retigabine dihydrochloride
Packaging
50mg
Price
$293
Updated
2021/12/16
ApexBio Technology
Product number
A3758
Product name
Retigabinedihydrochloride
Packaging
100mg
Price
$333
Updated
2021/12/16
ApexBio Technology
Product number
A3758
Product name
Retigabinedihydrochloride
Packaging
5mg
Price
$47
Updated
2021/12/16
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Retigabine Dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Drug interactions

 A clinical interaction study showed that there was no pharmacokinetic interaction between phenobarbitone and retigabine in healthy subjects. Thus, no dosage adjustment is likely to be necessary when phenobarbitone and retigabine are coadministered to patients 

Uses

A new experimental anticonvulsant drug. Anxiolytic.
Retigabine Dihydrochloride (0.1 ~ 10 μM) induced a potassium current and hyperpolarized CHO-KCNQ2/Q3 cells but not in wild-type cells. In the 6-Hz psychomotor seizure model, Retigabine Dihydrochloride dose-dependently blocked seizures induced by either 32 or 44 mA current stimulation.

Biological Activity

Retigabine is a first-in-class k+ channel (kcnq) opener. kcnq channels are reported to be expressed predominantly in neurons and are critical determinants of cellular excitability, as shown by the occurrence of human genetic mutations in kcnq channels which underlie inheritable disorders including the syndrome of benign familial neonatal convulsions.

in vitro

retigabine was found to combine a novel mode of actions, which were namely potassium channel opening (kcnq2, kcnq3 as well as kcnq4 channels). retigabine also showed activities with some potentiation of gamma amino butyric acid (gaba)-evoked currents at its higher concentrations [1].

in vivo

animal models of epileptic seizures showed that retigabine treatment was effective at an oral dose as low as 0.01 mg/kg. studies performed in mice also indicated that combining retigabine with another anticonvulsant agent leads to an additive effect [1].

References

[1] ferron gm,patat a,parks v,rolan p,troy sm. lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. br j clin pharmacol.2003 jul;56(1):39-45.

Retigabine Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Retigabine Dihydrochloride Suppliers

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View Lastest Price from Retigabine Dihydrochloride manufacturers

Hebei Guanlang Biotechnology Co,.LTD
Product
Tiotropium Bromide 150812-13-8
Price
US $11.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
10000kg
Release date
2021-07-05
Henan Aochuang Chemical Co.,Ltd.
Product
Retigabine Dihydrochloride 150812-13-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Wuhan Nutra Biotechnology Co.,Ltd
Product
Retigabine Dihydrochloride 150812-13-8
Price
US $0.00-0.00/g
Min. Order
10g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-27

150812-13-8, Retigabine DihydrochlorideRelated Search:


  • D 20443
  • Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate Dihydrochloride
  • N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester Dihydrochloride
  • Retigabine Dihydrochloride
  • Retigabine HCl
  • D 20443 dihydrochloride
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  • D-20443 dihydrochloride
  • ethyl 2-aMino-4-(4-fluorobenzylaMino)phenylcarbaMate dihydrochloride
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  • Retigabine DiHCl
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  • CS-2270
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  • Retigabine dihydrochloride- Bio-X
  • 150812-13-8
  • C16H20Cl2FN3O2
  • C16H18FN3O22HCl
  • C16H19ClFN3O2
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