6-AMIDINO-2-NAPHTHOL METHANESULFONATE

Product Name: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
CAS No.: 82957-06-0
Chemical Name: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
Synonyms: Nafamostat Impurity(Mesylate);6-Amidino-2-naphthol mesylate;Amidinonaphtolmethanesulfonate;Nafamostat Impurity 7 Mesylate;Nafamostat Impurity 10 Mesylate;Nafamostat Impurity 13 Mesylate;Nafamostat Impurity 16(Mesylate);Nafamostat mesylate Intermediate;6-aMidino-2-naphthol Methansulfonate;6-Amidino-2-naphtol methanesulfonate
CBNumber: CB7158685
Molecular Formula: C12H14N2O4S
Formula Weight: 282.32
MOL File: 82957-06-0.mol

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6-AMIDINO-2-NAPHTHOL METHANESULFONATE Property

Melting point:: 230 - 233°C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Acetonitrile (Slightly), DMSO (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C11H10N2O.CH4O3S/c12-11(13)9-2-1-8-6-10(14)4-3-7(8)5-9;1-5(2,3)4/h1-6,14H,(H3,12,13);1H3,(H,2,3,4)
InChIKey: NLLGCELWCUFUFD-UHFFFAOYSA-N
SMILES: C12C=CC(O)=CC=1C=CC(C(=N)N)=C2.S(=O)(=O)(O)C
CAS DataBase Reference: 82957-06-0(CAS DataBase Reference)

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Safety

HS Code: 2922.29.8190

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1193
Product name: 6-Amidino-2-naphthol Methanesulfonate
Purity: >99.0%(HPLC)(T)
Packaging: 1g
Price: $153
Updated: 2025/07/31

TCI Chemical

Product number: A1193
Product name: 6-Amidino-2-naphthol Methanesulfonate
Purity: >99.0%(HPLC)(T)
Packaging: 5g
Price: $446
Updated: 2025/07/31

TRC

Product number: A510060
Product name: 6-Amidino-2-naphthol Methanesulfonate
Packaging: 500mg
Price: $315
Updated: 2021/12/16

TRC

Product number: A510060
Product name: 6-Amidino-2-naphthol Methanesulfonate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA143848
Product name: 6-Amindino-2-naphtholmethanesulfonic acid
Packaging: 1g
Price: $80
Updated: 2021/12/16

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6-AMIDINO-2-NAPHTHOL METHANESULFONATE Chemical Properties,Usage,Production

Uses

6-Amidino-2-naphthol Methanesulfonate is a useful N-terminal derivatization reagent for improving peptide fragmentation.

Synthesis

52927-22-7

75-36-5

82957-06-0

1. Add 800 mL of anhydrous ethanol to a dry triple-necked flask, initiate stirring and cool the reaction system to 0-5 °C. 2. 430 mL of acetyl chloride was slowly added dropwise, and the rate of dropwise acceleration was controlled to maintain the reaction temperature at 0-5 °C. 3. 3. after the dropwise addition, keep the reaction system at 0-5°C for a period of time. 4. 85 g of 6-cyano-2-naphthol was added to the reaction system, warmed to 10 °C and kept for 10 hours. 5. After completion of the reaction, methyl tert-butyl ether was added, stirred for 1 hour and filtered. 6. The filter cake was washed with methyl tert-butyl ether, dried and mixed with ethanol. 7. The mixture was heated to 50°C and bubbled with dry ammonia for 3 hours. 8. 8. At the end of the reaction, the solvent was removed by evaporation under reduced pressure to give a yellow solid. 9. The solid was stirred with saturated sodium bicarbonate solution for a period of time, filtered and washed with water to neutral. 10. 10. Suspend the product in methanol and add appropriate amount of methanesulfonic acid solution dropwise. 11. 11. Add methyl tert-butyl ether to precipitate the solid, filter and wash with methyl tert-butyl ether. 12. Recrystallization was carried out with ethanol to give 75 g of a yellow solid product with a melting point of 227-230 °C and a yield of 53%.

References

[1] Patent: CN103896809, 2017, B. Location in patent: Paragraph 0010; 0011; 0012; 0013

6-AMIDINO-2-NAPHTHOL METHANESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMIDINO-2-NAPHTHOL METHANESULFONATE Suppliers

Americas 1 China 199 Europe 1 Germany 2 India 11 Japan 1 United Kingdom 5 United States 13 Global 233

Shanghai joygo pharmacetical tech., Co., Ltd.

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Energy Chemical

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View Lastest Price from 6-AMIDINO-2-NAPHTHOL METHANESULFONATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-Amidino-2-naphthol methanesulfonate 82957-06-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-02

Henan Aochuang Chemical Co.,Ltd.

Product: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE 82957-06-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Henan Fengda Chemical Co., Ltd

Product: 6-AMIDINO-2-NAPHTHOL METHANESULFONATE 82957-06-0
Price: US $35.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-27

82957-06-0, 6-AMIDINO-2-NAPHTHOL METHANESULFONATERelated Search:

BENZYLIDENE-2-NAPHTHYLAMINE 6-AMIDINO-2-NAPHTHOL METHANESULFONATE Methanesulfonic acid 6-Amidino-2-naphthyl-4-aminomethylbenzoate dimethanesulfonate NAPHTHALENE-2-CARBOXAMIDINE NAFAMOSTAT MESYLATE

6-Amidino-2-naphtol methanesulfonate

Amidinonaphtolmethanesulfonate

6-AMIDINO-2-NAPHTHOL METHANESULFONATE

6-AMIDINO-2-NAPHTHOL METHANESULFONIC ACID

6-Amidino-2-naphthol methanesulfonic acid (Nafamostat)

6-Amindino-2-naphtholmethanesulfonic acid

6-hydroxynaphthalene-2-carboxamidine mesylate

6-hydroxy-2-naphthiMidaMide Methanesulfonate

6-Hydroxy-2-naphthiMidaMide Methanesulfonate salt

6-aMidino-2-naphthol Methansulfonate

6-Amidino-2-naphthol methanesulfonate (Nafamostat mesylate)

Nafamostat mesylate Intermediate

6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid

6-Amidino-2-naphthol Methanesulfonate &gt

6-Carbamimidoyl-2-naphthol Methanesulfonate

6-Hydroxynaphthalene-2-carboximidamide Methanesulfonate

6-AMIDINO-2-NAPHTHOL METHANESULFONATE ISO 9001：2015 REACH

6- amidine-2 - naphthol methyl sulfonic acid

6-Amidino-2-naphthol methane sulfonate (NFT-III)

2-Naphthalenecarboximidamide, 6-hydroxy-, methanesulfonate (1:1)

6-hydroxy-2-Naphthalenecarboximidamide methanesulfonate (1:1)

6-Amidino-2-naphthol mehtane sulfonate

6-Hydroxy-naphthalen-2-carboximidamide methanesulfonate

6-methylamidin-2-naphthol methyl sulfonate

Nafamostat Impurity 16(Mesylate)

Nafamostat Impurity 10 Mesylate

NafamostNafamostat Impurity 16(Mesylate)at Impurity 16(Mesylate)

Nafamostat Impurity(Mesylate)

Nafamostat Impurity 7 Mesylate

6-Hydroxy-2-Naphthimidamide Methanesulfonic acid

6-Methylamino-2-naphthol methylsulfonate (Nafamostat mesylate)

6-Amidino-2-naphthol mesylate

Nafamostat Impurity 13 Mesylate

6-Formamido-2-naphthol methanesulfonate

82957-06-0

C11H10N2OCH4O3S

APIs Intermediate