2-CHLORO-4-(METHYLSULFONYL)ANILINE
- Product Name
- 2-CHLORO-4-(METHYLSULFONYL)ANILINE
- CAS No.
- 13244-35-4
- Chemical Name
- 2-CHLORO-4-(METHYLSULFONYL)ANILINE
- Synonyms
- 2-CHLORO-4-METHYLSULPHONYLANILINE;TIMTEC-BB SBB003494;LABOTEST-BB LT00441295;2-chloro-4-mesylaniline;2-chloro-4-(methylsulfonyl)-anilin;2-CHLORO-4-(METHYLSULFONYL)ANILINE;4-amino-3-chlorophenylmethylsulfone;4-amino-3-chlorofenylomethylosulfon;4-amino-3-chlorophenylmethylsulphone;2-Chloro-4-methylsulphonylaniline,95%
- CBNumber
- CB7160824
- Molecular Formula
- C7H8ClNO2S
- Formula Weight
- 205.66
- MOL File
- 13244-35-4.mol
2-CHLORO-4-(METHYLSULFONYL)ANILINE Property
- Melting point:
- 191-198 °C
- Boiling point:
- 400.1±45.0 °C(Predicted)
- Density
- 1.2326 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- pka
- -0.60±0.10(Predicted)
- form
- Crystalline Powder
- color
- Pale purple to gray-brown
- CAS DataBase Reference
- 13244-35-4(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenamine, 2-chloro-4-(methylsulfonyl)- (13244-35-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- S448281
- Product name
- 2-CHLORO-4-(METHYLSULFONYL)-ANILINE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 5972AA
- Product name
- 2-Chloro-4-(methylsulfonyl)aniline
- Packaging
- 1g
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 8663-5-01
- Product name
- 2-Chloro-4-(methylsulfonyl)aniline
- Packaging
- 5G
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 006907
- Product name
- 2-Chloro-4-methylsulfonylaniline
- Packaging
- 5g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 8663-5-01
- Product name
- 2-Chloro-4-(methylsulfonyl)aniline
- Packaging
- 25g
- Price
- $549
- Updated
- 2021/12/16
2-CHLORO-4-(METHYLSULFONYL)ANILINE Chemical Properties,Usage,Production
Chemical Properties
pale purple to grey-brown crystalline powder
Uses
2-Chloro-4-methylsulphonylaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes.
Synthesis
A mixture of 2-chloro-4-methylsulfonyl-1- nitro-benzene (4.5 g, 19.10 mmol, 1 eq.) in EtOH (40 mL) and a saturated NH4Cl solution (10 mL) was heated to 90 °C, and then Fe (3.20 g, 57.29 mmol, 3 eq.) was added in one portion. The reaction mixture was stirred at 90 °C for 1 h, after which time TLC analysis (PE:EtOAc = 1:1, Rf(starting material) = 0.7, Rf(product) = 0.31) indicated that the reaction was complete. The reaction was diluted with water (50 mL) and extracted with EtOAc (100 mL x 3). The combined organic layers were washed with water (50 mL x 3) and brine (50 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, PE:EtOAc = 4:1 to 2:1) to provide 2-chloro-4-methylsulfonyl-aniline (3.7 g, 17.99 mmol, 94.21% yield) as an off-white solid.
2-CHLORO-4-(METHYLSULFONYL)ANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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