ChemicalBook > CAS DataBase List > 2-amino-N,N-dimethylbenzenesulfonamide

2-amino-N,N-dimethylbenzenesulfonamide

Product Name
2-amino-N,N-dimethylbenzenesulfonamide
CAS No.
54468-86-9
Chemical Name
2-amino-N,N-dimethylbenzenesulfonamide
Synonyms
UKRORGSYN-BB BBV-033364;2-amino-N,N-dimethylbenzenesulfonamide;Benzenesulfonamide, 2-amino-N,N-dimethyl-;2-aMino-N,N-diMethylbenzene-1-sulfonaMide;2-amino-N,N-dimethylbenzenesulfonamide(SALTDATA: FREE)
CBNumber
CB71685986
Molecular Formula
C8H12N2O2S
Formula Weight
200.26
MOL File
54468-86-9.mol
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2-amino-N,N-dimethylbenzenesulfonamide Property

Melting point:
86-88 °C
Boiling point:
347.3±44.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
-0.12±0.10(Predicted)
color 
Pale Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A604585
Product name
2-Amino-N,N-dimethylbenzenesulfonamide
Packaging
5g
Price
$340
Updated
2021/12/16
ChemScene
Product number
CS-W021581
Product name
2-Amino-N,N-dimethylbenzenesulfonamide
Purity
≥98.0%
Packaging
1g
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J50949
Product name
2-Amino-N,N-dimethylbenzenesulfonamide
Packaging
1g
Price
$63
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA153590
Product name
2-Amino-N,N-dimethylbenzenesulfonamide
Packaging
500mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA153590
Product name
2-Amino-N,N-dimethylbenzenesulfonamide
Packaging
1g
Price
$125
Updated
2021/12/16
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2-amino-N,N-dimethylbenzenesulfonamide Chemical Properties,Usage,Production

Uses

2-Amino-N,N-dimethylbenzenesulfonamide is an intermediate used to prepare LDK378 as potent and selective anaplastic lymphoma kinase inhibitor.

Synthesis

23530-43-0

54468-86-9

General procedure for the synthesis of 2-amino-N,N-dimethylbenzenesulfonamide from N,N-dimethyl-2-nitrobenzenesulfonamide: N,N-dimethyl-2-nitrobenzenesulfonamide (2.5 g, 10.9 mmol) was dissolved in methanol (100 mL), and palladium/carbon catalyst (250 mg) was added. Hydrogen was introduced into the reaction system and the reaction mixture was stirred for 12 hours at room temperature. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration. The solvent was removed using a rotary evaporator to afford the target product 2-amino-N,N-dimethylbenzenesulfonamide (2 g, yield: 92%).

References

[1] Patent: EP3202765, 2017, A1. Location in patent: Paragraph 0157; 0158; 0146; 0147
[2] Patent: CN105524045, 2016, A. Location in patent: Paragraph 0261; 0262; 0263
[3] Russian Journal of General Chemistry, 1999, vol. 69, # 6, p. 962 - 968
[4] Patent: WO2004/22534, 2004, A1. Location in patent: Page 102
[5] Patent: US2014/271955, 2014, A1. Location in patent: Paragraph 0766; 0767

2-amino-N,N-dimethylbenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-amino-N,N-dimethylbenzenesulfonamide manufacturers

Career Henan Chemical Co
Product
2-Amino-N,N-dimethylbenzenesulfonamide 54468-86-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

54468-86-9, 2-amino-N,N-dimethylbenzenesulfonamideRelated Search:

2-Amino-N-ethylbenzenesulfonanilide POLYTHIAZIDE (200 MG) 1-(2-NITRO-BENZENESULFONYL)-PIPERAZINE TIMTEC-BB SBB006431 1-ACETYL-7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-(1H)-INDOLE [2-[2-[7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDROINDOL-1-YL]-1-METHYL-2-OXOETHYL]SULPHONYL]ACETIC ACID, METHYL ESTER 1-((4-(3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYL))PIPERAZINYL)SULFONYL)-2-NITROBENZENE 2-NITRO-1-((4-(5-(TRIFLUOROMETHYL)(2-PYRIDYL))PIPERAZINYL)SULFONYL)BENZENE 7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-1-[[N-[2-(TRIFLUOROMETHYL)PHENYL]AMINO]CARBONYL]-(1H)-INDOLE 1-[[N-(2,4-DIFLUOROPHENYL)AMINO]CARBONYL]-7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-(1H)-INDOLE 7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-1-[[N-(2-METHOXYPHENYL)AMINO]CARBONYL]-(1H)-INDOLE 7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-C-OXO-1-(1H)-INDOLEBUTANOIC ACID 1-(2,6-DIMETHOXYBENZOYL)-7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-(1H)-INDOLE [2-[2-[7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDROINDOL-1-YL]-1-METHYL-2-OXOETHYL]THIO]ACETIC ACID, METHYL ESTER 7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-1-[3-(TRIFLUOROMETHYL)BENZOYL]-(1H)-INDOLE 7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-1-(3-PHENYL-(2E)-PROPENOYL)-(1H)-INDOLE 2,3-DIHYDRO-N,N-DIMETHYL-7-(1H)-INDOLESULPHONAMIDE 7-(DIMETHYLAMINOSULPHONYL)-2,3-DIHYDRO-C-OXO-N-[3-(TRIFLUOROMETHYL)BENZYL]-(1H)-INDOLEBUTANAMIDE

  • 2-amino-N,N-dimethylbenzenesulfonamide
  • 2-amino-N,N-dimethylbenzenesulfonamide(SALTDATA: FREE)
  • 2-aMino-N,N-diMethylbenzene-1-sulfonaMide
  • UKRORGSYN-BB BBV-033364
  • Benzenesulfonamide, 2-amino-N,N-dimethyl-
  • 54468-86-9