ChemicalBook > CAS DataBase List > 5,6-DICHLOROBENZIMIDAZOLE
5,6-DICHLOROBENZIMIDAZOLE
- Product Name
- 5,6-DICHLOROBENZIMIDAZOLE
- CAS No.
- 6478-73-5
- Chemical Name
- 5,6-DICHLOROBENZIMIDAZOLE
- Synonyms
- NSC 6393;NSC 63938;NSC 326397;BUTTPARK 121\15-71;Astemizole Impurity 5;5, 6-dichlorobenidazole;5,6-DICHLOROBENZIMIDAZOLE;5,6-DICHLORO-1H-BENZIMIDAZOLE;1H-BENZIMIDAZOLE, 5,6-DICHLORO-;5,6-DICHLORO-1H-BENZO[D]IMIDAZOLE
- CBNumber
- CB7168794
- Molecular Formula
- C7H4Cl2N2
- Formula Weight
- 187.03
- MOL File
- 6478-73-5.mol
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5,6-DICHLOROBENZIMIDAZOLE Property
- Melting point:
- 205-206°
- Boiling point:
- 426.9±25.0 °C(Predicted)
- Density
- 1.571±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.74±0.30(Predicted)
- color
- Tan to Light Beige
- CAS DataBase Reference
- 6478-73-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- D5146
- Product name
- 5,6-Dichlorobenzimidazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $198
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D5146
- Product name
- 5,6-Dichlorobenzimidazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $591
- Updated
- 2025/07/31
TRC
- Product number
- D431900
- Product name
- 5,6-Dichlorobenzimidazole
- Packaging
- 2.5g
- Price
- $405
- Updated
- 2021/12/16
Usbiological
- Product number
- 009143
- Product name
- 5,6-Dichlorobenzimidazole
- Packaging
- 250mg
- Price
- $446
- Updated
- 2021/12/16
AK Scientific
- Product number
- V7109
- Product name
- 5,6-Dichlorobenzimidazole
- Packaging
- 5g
- Price
- $479
- Updated
- 2021/12/16
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5,6-DICHLOROBENZIMIDAZOLE Chemical Properties,Usage,Production
Chemical Properties
Purple Solid
Uses
A benzimidazole derivative as potent inhibitor of milk xanthine oxidase.
Synthesis
6478-78-0
6478-73-5
General procedure for the synthesis of 5,6-dichlorobenzimidazole from N-benzylbenzimidazole (CAS:6478-78-0, 208.1 mg, 1.0 mmol): to a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbling device under nitrogen protection were added N-benzylbenzimidazole, a dry Pd/C catalyst (10 wt%. 20 mg) and THF (5 mL). Subsequently, triethylsilane (320 μL, 2.0 mmol) was slowly added to the reaction mixture at room temperature and stirred continuously for 14 h under nitrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through a 0.45 μm PTFE syringe filter to remove the catalyst and the filtrate was concentrated under reduced pressure to remove the solvent. The residue was purified by column chromatography (eluent: 0 to 10% MeOH/dichloromethane gradient) to afford the target product 5,6-dichlorobenzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). It is worth noting that an induction period of 5 to 30 min usually exists at the beginning of the reaction, which is manifested by the beginning of gas release from the reaction mixture (i.e., the bubbling phenomenon). In addition, the use of a dry Pd/C catalyst is critical to the success of the reaction; wet Pd/C may result in a significant decrease in the reaction yield or no reaction at all.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 21, p. 2688 - 2690
5,6-DICHLOROBENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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