3-BROMO-5-IODO-PYRIDIN-4-YLAMINE
- Product Name
- 3-BROMO-5-IODO-PYRIDIN-4-YLAMINE
- CAS No.
- 902837-39-2
- Chemical Name
- 3-BROMO-5-IODO-PYRIDIN-4-YLAMINE
- Synonyms
- 3-bromo-5-iodopyridin-4-amine;3-bromo-5-iodo-4-Pyridinamine;4-AMINO-3-BROMO-5-IODOPYRIDINE;4-PyridinaMine, 3-broMo-5-iodo-;3-BROMO-5-IODO-PYRIDIN-4-YLAMINE;4-Amino-3-bromo-5-iodopyridine 95+%;3-BROMO-5-IODO-PYRIDIN-4-YLAMINE ISO 9001：2015 REACH
- CBNumber
- CB7169746
- Molecular Formula
- C5H4BrIN2
- Formula Weight
- 298.91
- MOL File
- 902837-39-2.mol
3-BROMO-5-IODO-PYRIDIN-4-YLAMINE Property
- Boiling point:
- 348.8±42.0 °C(Predicted)
- Density
- 2.426±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.19±0.24(Predicted)
- Appearance
- White to off-white Solid
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C5H4BrIN2/c6-3-1-9-2-4(7)5(3)8/h1-2H,(H2,8,9)
- InChIKey
- OGUAUXDOIHVFPA-UHFFFAOYSA-N
- SMILES
- C1=NC=C(I)C(N)=C1Br
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 3H30-S-00
- Product name
- 4-Amino-3-bromo-5-iodopyridine
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 2621AL
- Product name
- 4-Amino-3-bromo-5-iodopyridine
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 123468
- Product name
- 4-Amino-3-bromo-5-iodopyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $281
- Updated
- 2021/12/16
- Product number
- OR345153
- Product name
- 4-Amino-3-bromo-5-iodopyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $351
- Updated
- 2021/12/16
- Product number
- OR345153
- Product name
- 4-Amino-3-bromo-5-iodopyridine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $631
- Updated
- 2021/12/16
3-BROMO-5-IODO-PYRIDIN-4-YLAMINE Chemical Properties,Usage,Production
Synthesis
13534-98-0
902837-39-2
The general procedure for the synthesis of 3-bromo-5-iodopyridin-4-amine from 4-amino-3-bromopyridine was as follows: a solution was prepared by dissolving potassium iodide (2.88 g, 17.34 mmol) and iodine (2.75 g, 10.84 mmol) in water (21 mL). This solution was slowly added dropwise to a solution in water (10 mL) containing 4-amino-3-bromopyridine (2.5 g, 14.45 mmol) and sodium carbonate (0.919 g, 8.67 mmol). The reaction mixture was stirred under reflux conditions for 20 hours. After completion of the reaction, the mixture was diluted with water and ethyl acetate (EtOAc) and the aqueous and organic layers were separated. The aqueous layer was extracted three times with ethyl acetate and the organic layers were combined. The combined organic layers were washed three times with saturated sodium bicarbonate (NaHCO3) solution and sodium thiosulfate (Na2S2O3) solution sequentially. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), then filtered and the filtrate was concentrated in vacuum. The brown oil obtained was purified by silica gel column chromatography (using a Biotage system with the eluent cyclohexane/ethyl acetate in a ratio of 50:50 gradient to 0:100) to afford the target product 3-bromo-5-iodopyridin-4-amine (951 mg, 22% yield) and the unreacted raw material 4-amino-3-bromopyridine (1.66 g) as a light yellow solid.
References
[1] Journal of Organic Chemistry, 2012, vol. 77, # 11, p. 5006 - 5016
[2] Patent: US2016/16951, 2016, A1. Location in patent: Paragraph 0867; 0868
3-BROMO-5-IODO-PYRIDIN-4-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-BROMO-5-IODO-PYRIDIN-4-YLAMINE Suppliers
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 0512-67213637 13952409868
- peter19zhang@163.com
- Country
- China
- ProdList
- 442
- Advantage
- 55
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3992
- Advantage
- 55
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
View Lastest Price from 3-BROMO-5-IODO-PYRIDIN-4-YLAMINE manufacturers
- Product
- 3-BROMO-5-IODO-PYRIDIN-4-YLAMINE 902837-39-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-23
- Product
- 4-Amino-3-Bromo-5-Iodopyridine 902837-39-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
- Product
- 3-BROMO-5-IODO-PYRIDIN-4-YLAMINE 902837-39-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20