4-fluoro-2-isopropoxyaniline

Product Name: 4-fluoro-2-isopropoxyaniline
CAS No.: 148583-65-7
Chemical Name: 4-fluoro-2-isopropoxyaniline
Synonyms: 4-fluoro-2-isopropoxyaniline;4-Fluoro-2-isopropoxy-phenylamine;BenzenaMine, 4-fluoro-2-(1-Methylethoxy)-
CBNumber: CB71762180
Molecular Formula: C9H12FNO
Formula Weight: 169.2
MOL File: 148583-65-7.mol

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4-fluoro-2-isopropoxyaniline Property

Boiling point:: 237.0±20.0 °C(Predicted)
Density: 1.103±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.61±0.10(Predicted)
Appearance: Light brown to black Liquid
InChI: InChI=1S/C9H12FNO/c1-6(2)12-9-5-7(10)3-4-8(9)11/h3-6H,11H2,1-2H3
InChIKey: OCJQKVQIWUODTR-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(F)C=C1OC(C)C

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Safety

HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F592200
Product name: 4-Fluoro-2-isopropoxyaniline
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: PC900142
Product name: 4-Fluoro-2-isopropoxyaniline
Purity: 98%
Packaging: 1g
Price: $170
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4630-3-17
Product name: 4-Fluoro-2-(propan-2-yloxy)aniline
Purity: 97%
Packaging: 250mg
Price: $193
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4630-3-17
Product name: 4-Fluoro-2-(propan-2-yloxy)aniline
Purity: 97%
Packaging: 1g
Price: $395
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0359004
Product name: 4-FLUORO-2-ISOPROPOXYANILINE
Purity: 95.00%
Packaging: 1G
Price: $276.15
Updated: 2021/12/16

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4-fluoro-2-isopropoxyaniline Chemical Properties,Usage,Production

Synthesis

28987-46-4

148583-65-7

General procedure: 4-fluoro-2-isopropoxy-1-nitrobenzene (49.3 g, 248 mmol), ethanol (600 mL), and 10% Pd/C catalyst (50% aqueous solution, Degussa type E101; 10 g, equivalent to 20% of the mass of starting nitro compounds) were added to a round bottom flask. The flask was sealed with a rubber septum and three evacuation-hydrogen backfill cycles were performed to degas. The reaction mixture was stirred for 4 days at room temperature under hydrogen atmosphere (using a hydrogen balloon to maintain pressure). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed well with methanol. The filtrate and washings were combined and concentrated to dryness under reduced pressure to afford a brown liquid 4-fluoro-2-isopropoxyaniline (41.0 g, 98% yield), which can be used in subsequent reactions without further purification. The product was characterized as follows: 1H NMR (300 MHz, DMSO-d6) δ 6.67-6.72 (dd, 1H, J = 2.7, 11.0 Hz), 6.55-6.60 (dd, 1H, J = 6.0, 8.7 Hz), 6.43-6.49 (td, 1H, J = 2.7, 8.4 Hz), 4.47-4.55 (m , 3H), 1.23-1.25 (d, 6H, J = 6.0 Hz); 19F NMR (282 MHz, DMSO-d6) δ -127.4 (sextet); MS (ESI) m/z = 170 [M+H]+.

References

[1] Patent: WO2013/152198, 2013, A1. Location in patent: Paragraph 00588
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 539 - 550
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 1997 - 2009
[4] Patent: US6455528, 2002, B1

4-fluoro-2-isopropoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-fluoro-2-isopropoxyaniline Suppliers

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148583-65-7, 4-fluoro-2-isopropoxyanilineRelated Search:

4-fluoro-2-isopropoxyaniline

BenzenaMine, 4-fluoro-2-(1-Methylethoxy)-

4-Fluoro-2-isopropoxy-phenylamine

148583-65-7