Properties Stability and storage conditions Compatibility & incompatibility Production process Lactose intolerance
ChemicalBook > CAS DataBase List > D-Lactose monohy

D-Lactose monohy

Properties Stability and storage conditions Compatibility & incompatibility Production process Lactose intolerance
Product Name
D-Lactose monohy
CAS No.
14641-93-1
Chemical Name
D-Lactose monohy
Synonyms
Lactose;A-LACTIN;Lactose b;MILK SUGAR;A-LACTIN USP;A-MILK SUGAR;A-LACTOBIOSE;Lactose IP/BP;lactose bp/usp;.alpha.-Lactose
CBNumber
CB7177831
Molecular Formula
C12H22O11
Formula Weight
342.3
MOL File
14641-93-1.mol
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D-Lactose monohy Property

Melting point:
238 °C
Boiling point:
667.9±55.0 °C(Predicted)
Density 
1.76±0.1 g/cm3(Predicted)
refractive index 
52.5 ° (C=10, H2O)
storage temp. 
Inert atmosphere,Room Temperature
pka
12.02±0.70(Predicted)
Merck 
5343
CAS DataBase Reference
14641-93-1(CAS DataBase Reference)
EPA Substance Registry System
.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl- (14641-93-1)
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Safety

WGK Germany 
3
HS Code 
29400090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CRB0002886
Product name
ALPHA-LACTOSE
Purity
95.00%
Packaging
5MG
Price
$502.51
Updated
2021/12/16
Ambeed
Product number
A1004906
Product name
(2S,3R,4R,5S,6R)-6-(Hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol
Purity
98%DnasefreeandRnasefree
Packaging
1g
Price
$6
Updated
2021/12/16
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D-Lactose monohy Chemical Properties,Usage,Production

Properties

white or almost white crystalline granules or powder, odorless, slightly sweet. The sweetness of α-lactose is 15% of sucrose. The β-lactose has a higher sweetness than α-lactose. It is soluble in water, insoluble in alcohol, insoluble in ether and chloroform. The lactose monohydrate has a water content of 4.5% -5.5%, while the anhydrous hydrate has a water content of less than 1%. 9.75% (w / v) aqueous solution is isotonic with serum.

Stability and storage conditions

It is easily contaminated by mold in moist conditions (humidity greater than 80%). The color of lactose may turn brown as storage time is extended with moist and heat accelerating this change. Alpha-lactose monohydrate is stable in air and is unaffected by moisture at room temperature, but amorphous form of lactose is dependent on the degree of dryness and may be subject to moisture to be converted to monohydrate. Monohydrate, when heated to 120 ℃, can be converted into anhydrous. A saturated solution of beta-lactose may be precipitated into α-lactose crystals during placement, and the solution has a twisted optical rotation property. Lactose should be placed in airtight container and stored in a cool dry place.

Compatibility & incompatibility

Lactose can reacted with primary amine compounds to produce a brown product; the amorphous lactose is more likely participated into this reaction than crystalline lactose. Lactose has incompatibility with amino acids, aminophylline, amphetamine and isoniazid. Prescription containing tartrate, citrate or acetate, etc., or alkaline lubricants can accelerate the discoloration reaction.

Production process

Use the product of producing cheese or casein - whey as raw material, remove the protein content, followed by concentration, cooling, lactose crystallization and some other processes to obtain the dairy products. Mainly used in food industry, medicine and chemical reagents. Production process: raw whey material- → protein separation - →whey concentration - → cooling and crystallization of lactose - → molasses separation - → lactose washing - → drying (crude lactose) → refining treatment (refined lactose). Raw whey contains whey protein and a small amount of casein, which can be separated through adding line milk to the whey to pH 6.2 ~ 6.5 and simultaneously heating to over 90 ℃ for protein precipitation. Next, the cleared whey is then vacuumed concentrated to 35Be '(70% dry matter, Be' denotes Baume, a specific gravity unit) and cooled to 18-20 ° C for 24 hours to crystallize the lactose. In order to speed up the crystallization process and increase the yield, an appropriate amount of crystallization inducer (lactose powder or crystallized liquid lactose) can be added at the initial stage of crystallization. Crystal should be separated out of molasses using centrifugal dewatering machine and washed with water and finally dried to obtain crude lactose. In the dairy industry, refined lactose is usually produced, but since the crude lactose is yellow and contains more impurities, it needs to be refined before obtaining refined lactose. First, dissolve the crude lactose in warm water; add the decolorant (bone charcoal or activated charcoal) to decolorize; or use ion exchange resin for salt treatment; or use milk protein and calcium chloride for further removing the proteins. Then again apply concentration, drying to make refined lactose. The protein precipitate separated during the production of lactose can be used as a feed, and the separated molasses can also be used as a raw material for feed or lactic acid fermentation.

Lactose intolerance

Lactose digestion and malabsorption could be caused by congenital or secondary lactase deficiency. Lactase (β-galactosidase) catalyzes the hydrolysis of lactose to galactose and glucose, playing an important role in the digestion and absorption of lactose. Most babies contain high amount and high-activity intestinal lactase, being capable of fully digesting a large number of lactose in the diet. At about age 16, intestinal lactase begins to degenerate, and can finally lead to varying degrees of lactase deficiency in adults, which varies according their race. Infant lactase deficiency is mainly due to congenital or hereditary such as congenital intestinal mucosal abnormalities caused by lactase secretion dysfunction; can also be secondary to intestinal diseases such as Crohn's disease, ulcerative colitis, the virus Enteritis causes intestinal mucosa damage. Lactose intolerance can be prevented by removing or avoiding the presence of lactose in the diet. Infants can be feed with lactose-free formula while children can take well-fermented yogurt (in which the lactose has been converted by lactobacillus into lactic acid); adults should avoid drinking a lot of milk with empty stomach. Instead, you can first have a certain amount of other foods to reduce the relative concentration of lactose in the intestine so that bacteria are capable of decomposing it slowly with decomposition products being gradually absorbed.

Definition

ChEBI: The alpha-anomer of lactose.

General Description

In nature, it only exists in mammalian milk. It belongs to disaccharides, being composed of one molecule of glucose and one molecule of galactose with a sweetness of about 16. Milk contains about 4.3% ~ 4.5% of lactose. There are two isomers of lactose, namely, α-and β-type, being monohydrate and anhydrous, respectively. The α-lactose usually contains one molecule of crystal water with the melting point of 202 °C; β-type is as an anhydride with the melting point of 252 °C and has a higher sweetness and higher solubility than α-type. Lactose is made from whey, a by-product of cheese or casein, and is used in large quantities as a drug excipient, as a nutrient for infants and young children, and as a good medium for penicillin.
It is used as a diluent for soluble powder dispersions, oral capsules, powder inhalers and tablets; lactose is also used in lyophilisates and intravenous injections.

D-Lactose monohy Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Lactose monohy Suppliers

Shanghai Ruili Spectrum Biotechnology Co., Ltd
Tel
--
Fax
--
Email
1060496435@qq.com;sky20045@163.com
Country
China
ProdList
4573
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057- ;021-51691807
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com;peter.shi@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
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60
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
Hubei YuanCheng Pharmaceutical Co., Ltd.
Tel
18062666904
Fax
QQ:2355880546
Email
wyy01@ycphar.com
Country
China
ProdList
670
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65
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Bide Pharmatech Ltd.
Tel
021-61629020-8031;
Fax
+86-21-61629029
Email
sales@bldpharm.com;product07@bidepharm.com
Country
China
ProdList
44285
Advantage
60
Shanghai ideal Industrial Co., Ltd.
Tel
021-60899019
Fax
021-60899437
Email
adshiye@163.com
Country
China
ProdList
2882
Advantage
58
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View Lastest Price from D-Lactose monohy manufacturers

Career Henan Chemical Co
Product
Lactose 14641-93-1
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10MT
Release date
2018-12-16

14641-93-1, D-Lactose monohyRelated Search:


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  • 4-O-β-D-Galactopyranosyl-α-D-glucopyranose
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  • D(+)-LACTOSE HYDRATE
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  • BETA-D-GAL-(1->4)-ALPHA-D-GLC
  • BETA-D-GAL-(1->4)-ALPHA-D-GLC, MONOHYDRATE
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  • Disaccharides
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