ChemicalBook > CAS DataBase List > PKA Inhibitor Fragment (6-22) amide
PKA Inhibitor Fragment (6-22) amide
- Product Name
- PKA Inhibitor Fragment (6-22) amide
- CAS No.
- 121932-06-7
- Chemical Name
- PKA Inhibitor Fragment (6-22) amide
- Synonyms
- PKI (6-22) AMIDE;TYADFIASGRTGRRNAI;PKA Inhibitor Fragme;PKA INHIBITOR PEPTIDE;TYADFIASGRTGRRNAI-NH2;PKA Inhibitor 6-22 Amide;PKI INHIBITOR (6-22), AMIDE;PKI 6-22 AMIDE, PKA INHIBITOR;PKA INHIBITOR FRAGMENT (6-22) AMIDE;PROTEIN KINASE INHIBITOR (6-22) AMIDE
- CBNumber
- CB7180365
- Molecular Formula
- C80H130N28O24
- Formula Weight
- 1868.06
- MOL File
- 121932-06-7.mol
More
Less
PKA Inhibitor Fragment (6-22) amide Property
- storage temp.
- −20°C
- solubility
- ≥186.8 mg/mL in DMSO; insoluble in EtOH; ≥44.9 mg/mL in H2O
- form
- Solid
- Water Solubility
- Soluble to 1 mg/ml in water
More
Less
Safety
- WGK Germany
- 3
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- P6062
- Product name
- Protein Kinase A Inhibitor Fragment 6-22 amide
- Purity
- ≥97% (HPLC)
- Packaging
- 1mg
- Price
- $271
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 539684
- Product name
- PKA Inhibitor 6-22 Amide
- Packaging
- 1mg
- Price
- $201
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17486
- Product name
- PKA Inhibitor Fragment (6-22) amide
- Packaging
- 500μg
- Price
- $73
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17486
- Product name
- PKA Inhibitor Fragment (6-22) amide
- Packaging
- 1mg
- Price
- $131
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17486
- Product name
- PKA Inhibitor Fragment (6-22) amide
- Packaging
- 5mg
- Price
- $502
- Updated
- 2024/03/01
More
Less
PKA Inhibitor Fragment (6-22) amide Chemical Properties,Usage,Production
Biological Activity
ki: 1.6 nmpka inhibitor fragment (6-22) amide is a pka inhibitor.in cell biology, protein kinase a (pka) is a family of enzymes whose activity is dependent on cellular levels of cyclic amp (camp). pka is also regarded as a camp-dependent protein kinase. pka has various functions in the cell, such as regulation of sugar, glycogen, and lipid metabolism.
in vitro
compared with (ala)kemptide, pka inhibitor fragment (6-22) amide was found to have significant difference in inhibitory potency, likely due to the critical role of several of the nonarginine residues to this difference in potency. the minimal length analog of pka inhibitor fragment (6-22) that inhibited camp-dependent protein kinase with high potency was the 17-residue pki-(6-22)-amide. pka inhibitor fragment (6-22) interacted at the peptide/protein binding portion of the active site in a competitive manner with a low nanomolar ki value. to inhibit camp-dependent protein kinase, pka inhibitor fragment (6-22) required both the pseudosubstrate site (residues 14-22) and additional nh2-terminal determinants within residues 6-13. pka inhibitor fragment (6-22) could clear mimic protein and peptide substrates in interacting with the binding region of the active site particularly in the cooh-terminal pseudosubstrate basic domain. undoubtedly, the overall affinity of pka inhibitor fragment (6-22) was due to the number of hydrogen bonds as well as other bonding interactions with the active site of the camp-dependent protein kinase [1, 2].
storage
-20°C (desiccate)
References
[1] glass et al (1989) primary structural determinants essential for potent inhibition of camp-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. j.biol.chem. 264 8802. pmid: 2722799.
[2] glass et al (1989) protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. j.biol.chem. 264 14579. pmid: 2760075.
PKA Inhibitor Fragment (6-22) amide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
PKA Inhibitor Fragment (6-22) amide Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- +86-17380623303 +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4813
- Advantage
- 58
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 6968
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 22784
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30239
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 18115476705
- sales@tgpeptide.com
- Country
- China
- ProdList
- 3058
- Advantage
- 58
- Tel
- 0571-88211921 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 2890
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44806
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31121
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 24994
- Advantage
- 58
- Tel
- 0571-88211921 15572296305
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5178
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6659
- Advantage
- 58
- Tel
- 021-021-59178156 15300768757
- 359382369@qq.com
- Country
- China
- ProdList
- 10674
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 19961912513
- sales@hongtide.com
- Country
- China
- ProdList
- 4600
- Advantage
- 58
- Tel
- 021-34675735 19147740836
- 1986399151@qq.com
- Country
- China
- ProdList
- 9844
- Advantage
- 58
- Tel
- 13770887460
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1351
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 4988
- Advantage
- 58
- Tel
- 0512-51886999 17706251929
- office@combiosz.com
- Country
- China
- ProdList
- 2981
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 6813
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29979
- Advantage
- 58
- Tel
- 021-59555769 13524932310
- Fax
- 021-50342869
- 1405894150@qq.com
- Country
- China
- ProdList
- 8221
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4904
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 4997
- Advantage
- 58
- Tel
- 19135651983 19135651983
- 18611134419@163.com
- Country
- China
- ProdList
- 4416
- Advantage
- 58
- Tel
- 18059081430
- 2070812664@qq.com
- Country
- China
- ProdList
- 1232
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- bptsales@163.com
- Country
- China
- ProdList
- 3851
- Advantage
- 58
- Tel
- 18616537568
- hanfangpharma@126.com
- Country
- China
- ProdList
- 29971
- Advantage
- 58
- Tel
- +8619375158599
- info@molchanges.com
- Country
- China
- ProdList
- 5223
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10311
- Advantage
- 58
- Tel
- +8617531972939
- anna@api-made.com
- Country
- China
- ProdList
- 2943
- Advantage
- 58
- Tel
- +86-13347807150 +86-13347807150
- support@tgpeptide.com
- Country
- China
- ProdList
- 3279
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6025
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1920192055@qq.com
- Country
- CHINA
- ProdList
- 1843
- Advantage
- 58
- Tel
- --
- Fax
- --
- 912529879@qq.com
- Country
- CHINA
- ProdList
- 6835
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@neobioscience.com
- Country
- CHINA
- ProdList
- 6151
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2453006496@qq.com
- Country
- CHINA
- ProdList
- 6184
- Advantage
- 58
- Tel
- --
- Fax
- --
- marketing@4abio.com
- Country
- CHINA
- ProdList
- 6401
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15810802415@139.com
- Country
- CHINA
- ProdList
- 6750
- Advantage
- 58
121932-06-7, PKA Inhibitor Fragment (6-22) amideRelated Search:
Pro-AMC
PROTEASE INHIBITOR COCKTAIL, W/EDTA
1 VIAL PROTEASE-INHIBITOR-MIX G (31,2 MG)
PROTEASE FROM ASPERGILLUS ORYZEA
Ala-AMC
PROTEINASE K
EC 3.4.24.4
PROTEASE
LACTACYSTIN
PROTEASE
EC 3.4.21.14
Proteinase K
H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
CAMP DEPENDENT PK INHIBITOR (5-24) AMIDE
PKA Inhibitor Fragment (6-22) amide
H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP-OH
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-24) AMIDE
PROTEIN KINASE A INHIBITOR FRAGMENT 5-24 AMIDE TRIFLUOROACETATE SALT