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Artemifone

Product Name
Artemifone
CAS No.
255730-18-8
Chemical Name
Artemifone
Synonyms
Artemisone;Artemifone;BAY 44-9585;Artemisone, 10 mM in DMSO;YHVQDGXHTCSGBJ-AKSSTEKGSA-N;Cytomegalovirus,Inhibitor,Parasite,CMV,inhibit,Artemisone;10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin;(5aS,6R,8aR,12S)-3,6-dimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,10-dione;4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide;4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide
CBNumber
CB71856023
Molecular Formula
C19H31NO6S
Formula Weight
401.52
MOL File
255730-18-8.mol
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Artemifone Property

Boiling point:
536.5±50.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 130 mg/mL (323.77 mM)
form 
Solid
pka
2.99±0.20(Predicted)
color 
White to off-white
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Safety

HS Code 
9999999999
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0015600
Product name
Artemisone
Purity
98.09%
Packaging
5mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0045908
Product name
ARTEMISONE
Purity
95.00%
Packaging
5MG
Price
$454.93
Updated
2021/12/16
ChemScene
Product number
CS-0015600
Product name
Artemisone
Purity
98.09%
Packaging
10mg
Price
$550
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
33204
Product name
Artemisone
Packaging
1mg
Price
$590
Updated
2021/12/16
ChemScene
Product number
CS-0015600
Product name
Artemisone
Purity
98.09%
Packaging
50mg
Price
$1650
Updated
2021/12/16
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Artemifone Chemical Properties,Usage,Production

Uses

Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2].

in vivo

Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration[1].
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS[1]

IC 50

Plasmodium

References

[1] Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65. DOI:10.1093/jac/dkl563
[2] Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul.

Artemifone Preparation Products And Raw materials

Raw materials

Preparation Products

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Artemifone Suppliers

China 26 France 1 India 1 United States 7 Global 35
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255730-18-8, ArtemifoneRelated Search:

Artemisinin Arterolane Artesunate

  • Artemifone
  • 10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin
  • Artemisone
  • BAY 44-9585
  • YHVQDGXHTCSGBJ-AKSSTEKGSA-N
  • 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide
  • Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide
  • Cytomegalovirus,Inhibitor,Parasite,CMV,inhibit,Artemisone
  • (5aS,6R,8aR,12S)-3,6-dimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene-9,10-dione
  • 4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide
  • Artemisone, 10 mM in DMSO
  • 255730-18-8
  • C19H31NO6S