MK 0524

Product Name: MK 0524
CAS No.: 571170-77-9
Chemical Name: MK 0524
Synonyms: CS-623;MK 0524;Cardaptive;Laropiprant;Laropiprant, >=99%;Laropiprant(MK0524);MK-0524(Laropiprant)/;MK0524;LAROPIPRANT;MK-0524;Laropiprant, 10 mM in DMSO;[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
CBNumber: CB71872243
Molecular Formula: C21H19ClFNO4S
Formula Weight: 435.9
MOL File: 571170-77-9.mol

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MK 0524 Property

Melting point:: 175∶C
Boiling point:: 710.0±60.0 °C(Predicted)
Density: 1.48
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.45(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);11.47(Max Conc. mM)
form: Powder
pka: 4.54±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009835
Product name: MK-0524
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10009835
Product name: MK-0524
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 10009835
Product name: MK-0524
Purity: ≥98%
Packaging: 10mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 10009835
Product name: MK-0524
Purity: ≥98%
Packaging: 25mg
Price: $547
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0004752
Product name: LAROPIPRANT
Purity: 95.00%
Packaging: 5MG
Price: $800.42
Updated: 2021/12/16

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MK 0524 Chemical Properties,Usage,Production

Definition

ChEBI: Laropiprant is an indolyl carboxylic acid.

Biological Activity

MK-0524 is a potent and selective prostaglandin D2 (PGD2) receptor PTGDR (DP1) antagonist with inverse agonist activity (Ki = 570 pM/DP1, 2.95 nM/TP, 745 nM/DP2, >890 nM for EP1/2/3/4, FP and IP). MK-0524 inhibits cAMP accumulation in PGD2-challenged human platelets (IC50 = 90 pM) and blocks PGD2-induced nasal congestion in a sheep allergic rhinitis model in vivo (by 99% at 0.1 mg/kg i.v.). MK-0524 decreases DP1-dependent basal cAMP level in HEK293 (1-100 nM) without affecting DP1-dependent basal ERK1/2 phosphorylation (up to 1 μM).

storage

Store at -20°C

MK 0524 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK 0524 Suppliers

China 87 United States 17 Global 104

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18021050169
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

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View Lastest Price from MK 0524 manufacturers

Career Henan Chemical Co

Product: Laropiprant 571170-77-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

571170-77-9, MK 0524Related Search:

CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO- MK 0524

Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)-Laropiprant

MK 0524

Laropiprant

MK-0524(Laropiprant)/

Laropiprant(MK0524)

(3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid

[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

(R)-2-(4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Cardaptive

(3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid Laropiprant MK 0524

Laropiprant, >=99%

MK0524;LAROPIPRANT;MK-0524

CS-623

Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)-

Laropiprant, 10 mM in DMSO

571170-77-9

C21H19ClFNO4S