MK 0524
- Product Name
- MK 0524
- CAS No.
- 571170-77-9
- Chemical Name
- MK 0524
- Synonyms
- CS-623;MK 0524;Cardaptive;Laropiprant;Laropiprant, >=99%;Laropiprant(MK0524);MK-0524(Laropiprant)/;MK0524;LAROPIPRANT;MK-0524;Laropiprant, 10 mM in DMSO;[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
- CBNumber
- CB71872243
- Molecular Formula
- C21H19ClFNO4S
- Formula Weight
- 435.9
- MOL File
- 571170-77-9.mol
MK 0524 Property
- Melting point:
- 175∶C
- Boiling point:
- 710.0±60.0 °C(Predicted)
- Density
- 1.48
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.45(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);11.47(Max Conc. mM) - form
- Powder
- pka
- 4.54±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10009835
- Product name
- MK-0524
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 10009835
- Product name
- MK-0524
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 10009835
- Product name
- MK-0524
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 10009835
- Product name
- MK-0524
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $547
- Updated
- 2024/03/01
- Product number
- API0004752
- Product name
- LAROPIPRANT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $800.42
- Updated
- 2021/12/16
MK 0524 Chemical Properties,Usage,Production
Definition
ChEBI: Laropiprant is an indolyl carboxylic acid.
Biological Activity
MK-0524 is a potent and selective prostaglandin D2 (PGD2) receptor PTGDR (DP1) antagonist with inverse agonist activity (Ki = 570 pM/DP1, 2.95 nM/TP, 745 nM/DP2, >890 nM for EP1/2/3/4, FP and IP). MK-0524 inhibits cAMP accumulation in PGD2-challenged human platelets (IC50 = 90 pM) and blocks PGD2-induced nasal congestion in a sheep allergic rhinitis model in vivo (by 99% at 0.1 mg/kg i.v.). MK-0524 decreases DP1-dependent basal cAMP level in HEK293 (1-100 nM) without affecting DP1-dependent basal ERK1/2 phosphorylation (up to 1 μM).
storage
Store at -20°C
MK 0524 Preparation Products And Raw materials
Raw materials
Preparation Products
MK 0524 Suppliers
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View Lastest Price from MK 0524 manufacturers
- Product
- Laropiprant 571170-77-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10