ChemicalBook > CAS DataBase List > AMD 070

AMD 070

Product Name: AMD 070
CAS No.: 558447-26-0
Chemical Name: AMD 070
Synonyms: AMD 070;AMD-11070;Mavorixafor;AMD070/AMD-070;AMD-070 (AMD-11070);Mavorixafor(AMD-070);Mavorixafor, 10 mM in DMSO;Mavorixafor (AMD-070, X4P-001);N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI);AMD 070 N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)
CBNumber: CB71872364
Molecular Formula: C21H27N5
Formula Weight: 349.47
MOL File: 558447-26-0.mol

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AMD 070 Property

Melting point:: 108-110℃
Boiling point:: 597.0±50.0 °C(Predicted)
Density: 1.21
storage temp.: Store at -20°C
solubility: ≥17.45 mg/mL in DMSO; ≥44.5 mg/mL in EtOH; ≥7.47 mg/mL in H2O with gentle warming
form: oil
pka: 11.65±0.10(Predicted)
color: brown
InChIKey: WVLHHLRVNDMIAR-IBGZPJMESA-N
SMILES: C(N(CC1NC2=CC=CC=C2N=1)[C@@H]1C2=C(CCC1)C=CC=N2)CCCN

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28439
Product name: Mavorixafor
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 28439
Product name: Mavorixafor
Packaging: 10mg
Price: $186
Updated: 2024/03/01

TRC

Product number: B201930
Product name: N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine
Packaging: 25mg
Price: $475
Updated: 2021/12/16

ApexBio Technology

Product number: A3173
Product name: AMD-070
Packaging: 25mg
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0167492
Product name: N-((1H-BENZO[D]IMIDAZOL-2-YL)METHYL)-N-(4-AMINOBUTYL)-5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $500.95
Updated: 2021/12/16

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AMD 070 Chemical Properties,Usage,Production

Uses

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine is a potent CXCR4 inhibitor that inhibits X4 HIV-1 replication and the gp120/CXCR4 interaction. It also has therapeutic potential for developing treatments for B-RAF wild-type and mutated melanomas.

Definition

ChEBI: AMD 070 is an aminoquinoline.

in vivo

Mavorixafor (AMD-070) (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss^[2].

IC 50

¹²⁵I-SDF-CXCR4: 13 nM (IC₅₀); HIV-1 (NL4.3 strain): 1 nM (IC₅₀, in MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC₅₀, in PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, in MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, in PBMCs)

AMD 070 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMD 070 manufacturers

Career Henan Chemical Co

Product: AMD 070 558447-26-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

558447-26-0, AMD 070Related Search:

AMD 070

AMD-11070

N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)

N'-(1H-Benzimidazol-2-ylmethyl)-N'-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

AMD 070 N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)

1,4-ButanediaMine, N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-

(S)-N1-((1H-benzo[d]iMidazol-2-yl)Methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diaMine

AMD070/AMD-070

(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diami

1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-

N'-(1h-benzimidazol-2-ylmethyl)-n'-[(8s)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine

Mavorixafor

Mavorixafor(AMD-070)

Mavorixafor,CXCR,AMD 070,Human immunodeficiency virus,AMD070,HIV,inhibit,CXC chemokine receptors,Inhibitor

Mavorixafor (AMD-070, X4P-001)

Mavorixafor, 10 mM in DMSO

AMD-070 (AMD-11070)

558447-26-0