11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile

Product Name: 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
CAS No.: 309735-96-4
Chemical Name: 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
Synonyms: USP22-IN-1;Usp22i-S02;11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile;Benzimidazo[1,2-b]isoquinoline-6-carbonitrile, 7,8,9,10-tetrahydro-11-(phenylamino)-;11-(Phenylamino)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile
CBNumber: CB71884806
Molecular Formula: C22H18N4
Formula Weight: 338.41
MOL File: 309735-96-4.mol

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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Property

Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: -10 to -25°C
solubility: DMSO: 2mg/mL, clear
pka: 5.77±0.20(Predicted)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM1019728
Product name: 11-ANILINO-7,8,9,10-TETRAHYDROBENZIMIDAZO(1,2-B)ISOQUINOLINE-6-CARBONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $498.73
Updated: 2021/12/16

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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Chemical Properties,Usage,Production

Biological Activity

Cell-permeable and potent inhibitor of ubiquitin specific peptidase 22 (USP22) th at exhibits anticancer activity.

Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog th at is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner.

11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Suppliers

China 11 Finland 1 The Netherlands 1 United States 1 Global 14

Shanghai Chaolan Chemical Technology Center

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DC Chemicals

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Bide Pharmatech Ltd.

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ATK CHEMICAL COMPANY LIMITED

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309735-96-4, 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrileRelated Search:

11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile

Benzimidazo[1,2-b]isoquinoline-6-carbonitrile, 7,8,9,10-tetrahydro-11-(phenylamino)-

Usp22i-S02

USP22-IN-1

11-(Phenylamino)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile

309735-96-4