ChemicalBook > CAS DataBase List > 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
- Product Name
- 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
- CAS No.
- 309735-96-4
- Chemical Name
- 11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
- Synonyms
- USP22-IN-1;Usp22i-S02;11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile;Benzimidazo[1,2-b]isoquinoline-6-carbonitrile, 7,8,9,10-tetrahydro-11-(phenylamino)-;11-(Phenylamino)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile
- CBNumber
- CB71884806
- Molecular Formula
- C22H18N4
- Formula Weight
- 338.41
- MOL File
- 309735-96-4.mol
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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Property
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- -10 to -25°C
- solubility
- DMSO: 2mg/mL, clear
- pka
- 5.77±0.20(Predicted)
- form
- powder
- color
- white to beige
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- CHM1019728
- Product name
- 11-ANILINO-7,8,9,10-TETRAHYDROBENZIMIDAZO(1,2-B)ISOQUINOLINE-6-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.73
- Updated
- 2021/12/16
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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Chemical Properties,Usage,Production
Biological Activity
Cell-permeable and potent inhibitor of ubiquitin specific peptidase 22 (USP22) th at exhibits anticancer activity.
Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog th at is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner.
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
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