METHAMPICILLIN Property

Density 

1.46±0.1 g/cm3(Predicted)

pka

2.44±0.50(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

METHAMPICILLIN Chemical Properties,Usage,Production

Originator

Magnipen ,Clin-Comar-Byla ,Italy ,1969

Definition

ChEBI: A penicillin compound having a 6beta-(2R)-2-(methylideneamino)-2-phenylacetamido side-group.

Manufacturing Process

0.01 mol of 6-[D(-)α-(aminophenylacetamido)]-penicillanic acid was suspended in 150 cc of water cooled to +5°C and treated with 0.01 mol of sodium bicarbonate.
The solution was treated with 0.01 mol of formaldehyde in aqueous solution, with agitation. The solution was then filtered to eliminate traces of insoluble product and the filtrate was lyophilized. Sodium 6-[D(-)-alpha-(methyleneamino-phenylacetamido)]-penicillanate was obtained.

Therapeutic Function

Antibacterial