N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea

Product Name: N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea
CAS No.: 724453-98-9
Chemical Name: N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea
Synonyms: Diflapolin;Diflapolin, 10 mM in DMSO;1-(4-(Benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea;Urea, N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)-;N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea;N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea ISO 9001：2015 REACH;diseases,Inhibitor,permeability,neutrophil,Epoxide Hydrolase,Diflapolin,vascular,FLAP,infiltration,5-LO activating protein,inflammation,cysteinyl-LTs,inhibit
CBNumber: CB71962971
Molecular Formula: C22H17Cl2N3O2S
Formula Weight: 458.36
MOL File: 724453-98-9.mol

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N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Property

storage temp.: Store at -20°C
solubility: DMSO:42.0(Max Conc. mg/mL);91.63(Max Conc. mM)
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28103
Product name: Diflapolin
Packaging: 1mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 28103
Product name: Diflapolin
Packaging: 10mg
Price: $360
Updated: 2024/03/01

Cayman Chemical

Product number: 28103
Product name: Diflapolin
Packaging: 5mg
Price: $206
Updated: 2024/03/01

ChemScene

Product number: CS-0095399
Product name: Diflapolin
Purity: 99.42%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0095399
Product name: Diflapolin
Purity: 99.42%
Packaging: 25mg
Price: $300
Updated: 2021/12/16

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N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Chemical Properties,Usage,Production

Uses

Synthesis and structure-activity relationships of Diflapolin analogs as dual sol. Epoxide Hydrolase /5-Lipoxygenase-activating protein inhibitors.FLAP inhibitor.

in vivo

Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments^[1].

Animal Model:	Male CD-1 mice (zymosan-induced peritonitis mouse model)^[1]
Dosage:	1, 3 and 10?mg/kg
Administration:	I.p.; 30?min before zymosan injection
Result:	Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886.

N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Suppliers

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724453-98-9, N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)ureaRelated Search:

N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea

Diflapolin

Urea, N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)-

1-(4-(Benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea

N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea ISO 9001：2015 REACH

diseases,Inhibitor,permeability,neutrophil,Epoxide Hydrolase,Diflapolin,vascular,FLAP,infiltration,5-LO activating protein,inflammation,cysteinyl-LTs,inhibit

Diflapolin, 10 mM in DMSO

724453-98-9

C22H17Cl2N3O2S