6-nitrocoumarin

Product Name: 6-nitrocoumarin
CAS No.: 2725-81-7
Chemical Name: 6-nitrocoumarin
Synonyms: 6-NITROCOUMARIN;6-Nitrocoumarin>6-Nitrocoumarin, 98+%;6-nitro-2-benzopyrone;6-NITRO-2H-CHROMEN-2-ONE;6-Nitro-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 6-nitro-;N-[4-[(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepin-6-yl)-oxomethyl]phenyl]-2-phenylbenzamide hydrochloride
CBNumber: CB7202339
Molecular Formula: C9H5NO4
Formula Weight: 191.14
MOL File: 2725-81-7.mol

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6-nitrocoumarin Property

Melting point:: 186 °C
Boiling point:: 326.87°C (rough estimate)
Density: 1.4625 (rough estimate)
refractive index: 1.4500 (estimate)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
color: White to Orange to Green
BRN: 166079
CAS DataBase Reference: 2725-81-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 40-22
Safety Statements: 22-24/25-36-37/39-26
HS Code: 2932.20.4500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: N0923
Product name: 6-Nitrocoumarin
Purity: >98.0%(GC)
Packaging: 5g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: N0923
Product name: 6-Nitrocoumarin
Purity: >98.0%(GC)
Packaging: 25g
Price: $156
Updated: 2025/07/31

Usbiological

Product number: 234805
Product name: 6-Nitrocoumarin
Packaging: 1g
Price: $163
Updated: 2021/12/16

Usbiological

Product number: 285848
Product name: 6-Nitrocoumarin
Packaging: 10g
Price: $232
Updated: 2021/12/16

TRC

Product number: N497170
Product name: 6-Nitro-2H-chromen-2-one
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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6-nitrocoumarin Chemical Properties,Usage,Production

Synthesis

91-64-5

2725-81-7

The method was carried out with reference to the literature (Roy et al., 2011). In a 250 mL three-necked flask equipped with a condenser tube, thermometer and dropping funnel, coumarin (10 g, 68.5 mmol) and 50 mL of concentrated sulfuric acid (0.935 mol) were added. After cooling the reaction system to -10 °C, a mixture consisting of concentrated sulfuric acid (15 mL, 0.28 mol) and fuming nitric acid (5 mL, 0.12 mol) was added slowly and dropwise over a period of 1 hour, during which the reaction temperature was kept below -5 °C. Upon completion of the reaction, the mixture was decanted into ice water, the precipitate was collected by filtration and recrystallized from acetic acid. A white solid 11.26 g of 6-nitro-2H-benzopyran-2-one was obtained in 86% yield with a melting point of 191-192.5 °C (literature value 188-190 °C). The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (400.13 MHz, CDCl3) δ 6.60 (d, J = 9.5 Hz, 1H), 7.48 (d, J = 9.0 Hz, 1H), 7.83 (d, J = 9.5 Hz, 1H), 8.42 (dd, J = 9.0 Hz, 2.5 Hz, 1H). 8.46 (d, J = 2.5 Hz, 1H); 13C NMR (100.62 MHz, CDCl3) δ 118.1, 118.8, 118.8, 123.7, 126.6, 142.2, 144.0, 157.5, 158.8.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 5894 - 5901
[2] Synthetic Communications, 2001, vol. 31, # 2, p. 301 - 309
[3] Molecular Pharmacology, 1995, vol. 48, # 6, p. 1063 - 1067
[4] Polyhedron, 2011, vol. 30, # 6, p. 913 - 922
[5] Journal of Inorganic Biochemistry, 2011, vol. 105, # 4, p. 577 - 588

6-nitrocoumarin Preparation Products And Raw materials

Raw materials

Preparation Products

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6-nitrocoumarin Suppliers

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2H-1-Benzopyran-2-one, 6-nitro-

N-[4-[(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepin-6-yl)-oxomethyl]phenyl]-2-phenylbenzamide hydrochloride

6-NITROCOUMARIN

6-NITRO-2H-CHROMEN-2-ONE

6-nitro-2-benzopyrone

6-Nitrocoumarin, 98+%

6-Nitro-2H-1-benzopyran-2-one

6-Nitrocoumarin&gt

2725-81-7

Coumarins